底丘脑核深部脑电刺激对大鼠呼吸的影响  

Effect of Subthalamic Nucleus-Deep Brain Stimulation on Breath Frequency of Rats

作　　者：钱坤[1] 曹春燕 刘振国[1] 沈国舜[2] 

机构地区：[1]上海交通大学医学院新华医院神经内科,上海200092 [2]上海交通大学基础医学院生理学教研室,上海200092

出　　处：《上海交通大学学报（医学版）》2006年第11期1264-1266,共3页Journal of Shanghai Jiao tong University:Medical Science

基　　金：教育部留学回国人员科研启动基金资助项目

摘　　要：目的研究底丘脑核(STN)的深部脑电刺激(DBS)对大鼠呼吸的影响。方法24只SD大鼠随机分为4组(n=6):对照组(无刺激)、高频强电流组(130 Hz/100μA)、高频弱电流组(130 Hz/3μA)和低频强电流组(40 Hz/100μA)。利用大鼠脑立体定向仪将电极植入右侧STN,记录刺激前、刺激第5和第25分钟的呼吸频率。结果高频强电流组和高频弱电流组刺激前呼吸频率分别为(68.0±7.9)和(71.8±6.7)次/m in;刺激后第5分钟的呼吸频率分别为(57.8±10.6)和(65.8±7.8)次/m in;第25分钟的呼吸频率分别为(49.8±8.9)和(56.0±9.2)次/m in;同组各时间点的呼吸频率变化有统计学意义(P<0.05)。低频强电流组和对照组各时间点的呼吸频率无明显变化(P>0.05)。结论大鼠在高频率DBS下呼吸频率减慢,但与刺激强度关系不大。Objective To study the effect of subthalamic nucleus（STN）-deep brain stimulation （DBS） on breath frequency of rats. Methods Twenty-four SD rats were divided into four groups randomly ： non-stimulation（control） group, high-frequency and high-intensity（130 Hz/100μA）group, high-frequency and low-intensity（130 Hz/3 μA） group and low-frequency and high-intensity（40 Hz/100μA）group. The target of DBS was STN which was located by stereotactic apparatus. Breath frequencies of rats were recorded at the time of pre-stimulation, 5 and 25 min after execution of stimulation. Results In the 130 Hz/100μA group, the breath frequency of rats was （68.0± 7.9）/min at pre-stimulation, and decreased to （57.8 ±10.6）/min after execution of stimulation for 5 min, and to （49.8 ± 8.9）/min after execution of stimulation for 25 min. In the 130 Hz/3μA group, the breath frequencies of rats at different stages were （71.8 ± 6.7）, （65.8± 7.8） and （56.0 ± 9.2）/min, respectively. There were significant differences on breath frequency among the different time points in the 130 Hz/100μA group and the 130 Hz/3μA group （P 〈0.05）. However, in the control group and the 40 Hz/100μA group, there were no significant differences on breath frequency at any stage of stimulation （P 〉 0.05）. Conclusion The effects of DBS on breath frequency of rats may be related to frequency rather than intensity of stimulation.

关 键 词：深部脑电刺激 底丘脑核 呼吸 频率 

分 类 号：R741[医药卫生—神经病学与精神病学]