血浆心房钠尿肽的变化与急性脑卒中的关系  

Changes in Atrial Natriuretic Factor Level in Plasma in Patients with Acute Strokes

作　　者：刘举珍[1] 李润今[1] 

机构地区：[1]内蒙古自治区医院神经内科,呼和浩特010017

出　　处：《神经损伤与功能重建》2006年第4期217-218,共2页Neural Injury and Functional Reconstruction

摘　　要：目的:探讨急性脑卒中患者血浆心房钠尿肽(ANP)的变化及其临床意义。方法:对76例脑梗死患者(脑梗死组)和16例脑出血患者(脑出血组)于发病后第1、2、3周采用放射免疫法测定血浆ANP水平,以30例健康体检者(对照组)的血浆ANP水平作为对照。结果:在发病后各时间点,脑梗死组和脑出血组血浆ANP水平均明显高于对照组(P<0.01)。发病后第1周脑出血组血浆ANP水平明显高于脑梗死组(P<0.05),第2、3周仍高于脑梗死组,但差异均无显著性意义。2组发病后第1周与第2周比较差异均无显著性意义。结论:血浆ANP水平的增高在一定程度上反映了脑组织受损的严重程度,也与高血压和机体的应激反应有关。Objective： The changes of atrial natriuretic factor （ANP） level in plasma in patients with acute strokes and its clinical significance have been investigated. Methods： Seventy-six patients with cerebral infarction and 16 cases with cerebral hemorrhage were checked for ANP levels at weeks 1, 2 and 3 after onset of the strokes using radioimmunoassay. Thirty normal controls were studied. Results： The levels of ANP in plasma in patients who suffered from either ischemia or hemorrhages were significantly increased when compared to those in the normal controis （P〈0.01）. The blood levels of NAP in hemorrhagic patients were significantly higher than those in cases with infarction at week 1 after onset （P〈0.05）. Conclusion： The increased ANP level in plasma in patients with strokes may be related to the severity of damage to the brain tissues. In addition, high blood pressure and stress may be responsible for the change in part.

关 键 词：脑梗死 脑出血 心房钠尿肽 高血压 

分 类 号：R741[医药卫生—神经病学与精神病学] R743.3[医药卫生—临床医学]