microRNA与肿瘤相关性研究进展  

Progresses on the study of microRNA and cancer

作　　者：杜莉莉[1] 管晓翔[1] 陈龙邦[1] 

机构地区：[1]南京军区南京总医院南京大学医学院临床学院肿瘤科,江苏南京210002

出　　处：《医学研究生学报》2006年第11期1024-1027,共4页Journal of Medical Postgraduates

基　　金：国家自然科学基金资助项目(批准号:30470669)

摘　　要：m icroRNA(m iRNA)是真核生物中一类长度约为22个核苷酸、参与基因转录后水平调控的非编码小分子RNA。近年来研究发现,m iRNA除了具有调控细胞增殖、死亡、细胞分化、个体发育等生物学功能以外,与肿瘤的发生也有着密切的关系。该文作者试图从m iRNA的生物学特性、形成、生理功能、作用机制及与肿瘤的关系等方面的研究进展作一综述。microRNA with 22 nucleotides in length are a growing family of small non -coding RNA that function as post-transcriptional regulators of target genes in eukaryote. Recent study indicates that microRNA are closely related to the oncogenesis additional to its biological function in the regulation of cell proliferation, differentiation and death. This review proposes the progresses on the study of microRNA, including the biological character, biogenesis and function, and its relationship with cancer.

关 键 词：MICRORNA 非编码RNA 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]