染色体不稳定性与肿瘤  

Chromosomal Instability and Cancer

作　　者：徐铭[1] 刘炳亚[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院外科上海消化外科研究所,上海市200025

出　　处：《医学分子生物学杂志》2006年第6期430-433,共4页Journal of Medical Molecular Biology

基　　金：国家重点基础研究发展规划项目(973计划)(No.2002CB713700)~~

摘　　要：染色体不稳定性是癌细胞的一个普遍特征,并且可能是肿瘤形成的重要机制。绝大多数肿瘤表现为染色体不稳定性。多种细胞机制功能障碍将导致染色体不稳定性,包括染色体分离、DNA损伤反应、细胞周期检查点、端粒功能等。通过分子和细胞生物学研究揭示了一些染色体不稳定性可能的分子机制及其与肿瘤发生的关系。从而为肿瘤发生的分子机制的研究拓展了新的视野,为肿瘤的诊断、分型、治疗、预后提供了新的思路。Chromosomal instability （CIN） is a common feature of cancer cells. The persistent presence of CIN has been demonstrated in majority of human cancers, especially in solid tumors. Several factors, such as defects in chromosome segregation and DNA damage response, failure of cell cycle checkpoint, telomere dysfunction, may cause chromosomal instability. Recent progresses in molecular and cellular biology as well as cytogenetics have shed light on the possible molecular mechanisms of CIN and its association with carcinogenesis. These researches provide new insight into the molecular mechanisms of carcinogenesis and provide new ideas in diagnosis, therapy, classification, and prognosis of cancer.

关 键 词：染色体不稳定性 肿瘤 分子机制 

分 类 号：R394.224[医药卫生—医学遗传学]