Dicer酶及其在RNA干扰中的作用  

Dicer and Its Functions in RNA Interference

作　　者：胡妙凤[1] 尚世强[1] 

机构地区：[1]浙江大学医学院附属儿童医院中心实验室,杭州市310003

出　　处：《医学分子生物学杂志》2006年第6期468-471,共4页Journal of Medical Molecular Biology

摘　　要：RNA干扰(RNAInterference,RNAi)是双链RNA引起的同源mRNA特异性降解的现象。Dicer酶是核糖核酸酶Ⅲ(RibonucleaseⅢ,RNaseⅢ)家族的成员,在RNA干扰的起始阶段起着重要作用。Dicer酶最早在果蝇中发现,包括Dicer-1和Dicer-2,分别以Dicer-1/R3D1-L、Dicer-2/R2D2复合物的形式作用于微小RNA(microRNA,miRNA)和小干扰RNA(smallinterferingRNA,siRNA)的产生。Dicer酶除了在RNAi中发挥重要作用外,还在调节动物生殖发育中起作用。RNA Interference is a sequence-specific RNA degradation process mediated by double-stranded RNA. Dicer, a member of RNase Ⅲ family, plays an important role in the initial steps of RNA Interference. Dicer, including Dicer-1 and Dicer-2, was first discovered in Drosophi-1a. Two complexes, Dicer-1/R3D1-L and Dicer-2/R2D2 can produce mieroRNA （miRNA） and small interfering RNA （siRNA） respectively. In addition to its function in RNAi, Dicer also regulates reproductive development in animals.

关 键 词：DICER酶 RNA干扰 小干扰RNA 微小RNA 

分 类 号：R394[医药卫生—医学遗传学]