DNA中的B-Z“链接”  

The Junction between B-DNA and Z-DNA

作　　者：周盼盼[1] 王丽娟[1] 邱文元[1] 

机构地区：[1]兰州大学化学系功能有机分子化学国家重点实验室,兰州730000

出　　处：《化学通报》2006年第11期822-825,共4页Chemistry

基　　金：国家自然科学基金(20173023;90203012);高等学校博士点基金(20020730006)资助项目

摘　　要：DNA能够通过改变自身的构象来完成它在生命过程中的一些重要作用。在进行转录和其它一些生理过程中,B-DNA的局部区域会转变为Z-DNA,形成具有两个B-Z接合点的奇特的B-DNA-Z-DNA-B-DNA结构,在每个接合点处有一对碱基的氢键发生断裂且碱基被挤出而连接在双螺旋的外侧。探讨这种结构的形成机制对于理解DNA的结构与功能的关系具有重要意义,也将有助于更深刻地认识Z-DNA所扮演的角色。DNA can shape itself into many forms to achieve its significant purposes in life. Local structure of B-DNA would turn into Z-DNA as a result of transcription or other physiological processes, The peculiar B-DNA-Z-DNA-B-DNA structure, which has two B-Z junctions, is formed by breaking of one base pair at the junction and extrusion of the bases on each side. Discussing the formation of this structure is significant to understand the relationship between the structure and function of DNA, and it will also be helpful to realize profoundly the important role of Z-DNA.

关 键 词：双螺旋 B-DNA Z-DNA B-Z“链接” 构象 

分 类 号：Q523[生物学—生物化学]