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Z-DNA: 作品数：30被引量：21H指数：3; 导出分析报告; 相关领域：生物学更多>>; 相关作者：胡成钰吴初新闫循领董瑞新汤雅男更多>>; 相关机构：南昌大学聊城大学中国科学院安徽大学更多>>; 相关期刊：《自然与科技》《Acta Biochimica et Biophysica Sinica》《Journal of Rare Earths》《Acta Pharmacologica Sinica》更多>>; 相关基金：国家自然科学基金国家教育部博士点基金山东省自然科学基金国家重点基础研究发展计划更多>>

Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages: 《Acta Pharmacologica Sinica》2025年第2期430-447,共18页Yi-ping You Liang Yan Hua-yu Ke Ya-ping Li Zi-jian Shi Zhi-ya Zhou Hai-yan Yang Tao Yuan Ying-qing Gan Na Lu Li-hui Xu Bo Hu Dong-yun Ou-Yang Qing-bing Zha Xian-hui He; supported by the grants from the National Natural Science Foundation of China(82274167,81773965,and 81873064);the Science and Technology Project of Heyuan,China(Social Development and Rural Science No.2023008);the Project of Guangdong Administration of Traditional Chinese Medicine(20232177).; PANoptosis is an emerging form of regulated cell death(RCD)characterized by simultaneous activation of pyroptotic,apoptotic,and necroptotic signaling that not only participates in pathologies of inflammatory diseases ...; 关键词：MACROPHAGES PANoptosis BAICALIN mitochondrial Z-DNA ZBP1 hemophagocytic lymphohistiocytosis

Z型核酸的形成及生物学功能研究进展: 《中国海洋大学学报（自然科学版）》2024年第10期113-133,共21页梁兴国刘梦琴安然张亚萍; 国家自然科学基金青年科学基金项目(32102064);国家重点研究发展计划项目(2019YFC1604603);青岛市自然科学基金项目(24-4-4-zrjj-147-jch)资助。; 近年来,具有左旋双螺旋结构的Z型核酸(包括Z-DNA和Z-RNA)的重要生物学功能不断被发现,但Z型核酸(ZNA)在体内的形成及发挥功能的机制仍然不清楚。一般Z型核酸本身并不能稳定存在,易转化为右旋双螺旋结构,需要通过与其特异性结合蛋白(如...; 关键词：Z-DNA Z-RNA 核酸结构拓扑限制 B-Z转变

Z-DNA marks the spot for AIRE: 《Cell Research》2024年第8期537-538,共2页Yael Goldfarb Jakub Abramson; Autoimmune regulator(AIRE)is a unique transcriptional regulator that induces ectopic expression of thousands of tissue-specific genes in the thymus,a step critical for the establishment of immunological tolerance to s...; 关键词：GENES TRANSCRIPTIONAL critical

Inducing Z-DNA overcomes immune checkpoint blockade resistance被引量：1: 《Cell Research》2022年第10期871-872,共2页Huipeng Jiao Manolis Pasparakis; Inducing immunogenic cell death in tumors holds promise in stimulating anti-tumor immunity.A recent study published in Nature reported that a small molecule previously shown to induce the formation of Z-DNA activates ...; 关键词：ADAR1 RESISTANCE RENDER

Presence/Absence of Two Types of Z-DNA Binding Domains in the Genomes of Organisms from Archaea, Bacteria, and Eukaryotes and Its Implications: 《Journal of Biomedical Science and Engineering》2019年第1期1-9,共9页Hiroshi Nakashima; We conducted genome sequence analysis to examine the presence/absence of two types of Z-DNA binding domains in various organisms. We examined 68 organisms from archaea, 914 organisms from bacteria, and 199 organisms f...; 关键词：Z-DNA Binding Domain RECA Protein Adenosine DEAMINASE Acting on RNA Genome Sequence Analysis

d（GC）n repeats form Z-DNA within promoter region and repress the promoter activity in Escherichia coil被引量：1: 《Acta Biochimica et Biophysica Sinica》2015年第7期567-569,共3页Shenghe Huang Chuxin Wu Dongming Li Haizhou Wang Zechang Rao Qiling Shen Chunxiang Chen Yong Liu Xun Xu Chengyu Hu; This work was supported by the grants from the National Natural Science Foundation of China （Nos. 31360515 and 31472304） and the Science and Technology Project of Fuzhou Medical College （No. CDFY-KJ1402）.; Z-DNA is a left-handed helical form of DNA in which sugarphosphate backbone winds in a zig-zag pattern. DNA containing alternating purine and pyrimidine repeats has the potential to adopt the Z-DNA formation. In vivo,...

Helical Configurations of Elastic Rods in the Presence of Interfacial Traction: 《Transactions of Tianjin University》2015年第3期223-227,共5页王永昭张琪昌王炜韩建鑫; Supported by the National Nature Science Foundation of China(No.11372210);the Research Fund for the Doctoral Program of Higher Education of China(No.20120032110010);Tianjin Research Program of Application Foundation and Advanced Technology(No.12JCZDJC28000); The Kirchhoff thin elastic rod models are always the important basis to explore the configuration mecha- nism of the flexible structures in both the macroscopic and microscopic scale. As a continuum model of DNA, a th...; 关键词：interfacial energy static Kirchhoff＇s equations helical configuration ionic concentration B-DNA to Z-DNA transition

Z-DNA与人类疾病: 《生物医学》2014年第2期17-21,共5页周文琪陈诗哲马天骏李金明郭艳芳; 国家自然科学基金面上项目(31371290);广东省高校人才引进专业(粤财字2011-430);高等学校博士学科点专项科研基金(20124433120006);广东省优秀青年人才培养项目(LYM11040)。; Z-DNA在1979年被Rich等人发现,它处于高能状态而不稳定,不同于传统的B-DNA,Z-DNA以其特殊的构象和重要生物学功能越来越受到人们关注,与其作用相关的Z-DNA结合蛋白也备受关注。Z-DNA有其特殊的序列和形成条件,其重要生物学功能也逐渐被...; 关键词：Z-DNA Z-DNA结合蛋白人类疾病基因调控

G-四链体:核酸的“新”结构被引量：1: 《生命的化学》2014年第4期583-588,共6页郭晓强; 核酸（包括DNA和RNA）是体内最重要一类生物大分子,DNA主要作为遗传信息载体,而RNA则作为信息中介分子、调节因子和酶等发挥多重生物学功能。核酸分子空间结构形式复杂、可变,可采用多种构象,在体内DNA主要为双螺旋结构,而RNA采取单链...; 关键词：双螺旋结构 G-四链体核酸 Z-DNA 生物大分子信息载体生物学功能分子空间

Z-DNA的发现者——里奇被引量：1: 《生命的化学》2014年第1期69-74,共6页郭晓强; 1953年，沃森和克里克双螺旋模型的提出标志着现代分子生物学诞生，从而使生命科学研究进入了一个崭新的时代。在随后的一段时间内，生命科学领域取得了一系列辉煌的成就，诞生了大量科学大师和伟大科学家。许多工作都获得了诺贝尔奖，...; 关键词：Z-DNA 现代分子生物学发现者科学研究生命科学诺贝尔奖双螺旋模型研究成果

Z-DNA