Z-DNA marks the spot for AIRE  

作　　者：Yael Goldfarb Jakub Abramson 

机构地区：[1]Department of Immunology and Regenerative Biology,Weizmann Institute of Science,Rehovot,Israel

出　　处：《Cell Research》2024年第8期537-538,共2页细胞研究（英文版）

摘　　要：Autoimmune regulator(AIRE)is a unique transcriptional regulator that induces ectopic expression of thousands of tissue-specific genes in the thymus,a step critical for the establishment of immunological tolerance to self.In their recent publication,Fang et al.provide novel mechanistic insights into AIRE’s modus operandi,by highlighting Z-DNA as a key cis-regulatory element,critical for guiding AIRE to its target genes.

关 键 词：GENES TRANSCRIPTIONAL critical 

分 类 号：Q52[生物学—生物化学]