TRANSCRIPTIONAL

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Transcriptional programs associated with luminal play a vital role in invasive mucinous lung adenocarcinoma
《Genes & Diseases》2025年第2期21-24,共4页Shufan Zhang Rong Jiang Changguo Wang Manqiu Yang Tao Wang Jianzhou Cui Guangbin Li Shaomu Chen Moli Huang 
supported by the National Natural Science Foundation of China (No.32370598,31971117);the National Key R&D Program of China (No.2018YFA0801100);the Natural Science Foundation of Suzhou,Jiangsu,China (No.SYS201517);the Priority Academic Program Development of Jiangsu Higher Education Institutions (China)。
Invasive mucinous lung adenocarcinoma(IMAi)san aggressive subtype characterized by the presence of tumor cells with goblet cell morphology and abundant intracytoplasmic mucin.A previous study had shown that all epithe...
关键词：ADENOCARCINOMA LUMINAL MUCINOUS 
Phosphorylation modification reverses the transcriptional inhibitory activity of CsMYB4a in tea plants(Camellia sinensis)
《Horticultural Plant Journal》2025年第1期406-416,共11页Guoliang Ma Yunyun Han Tongtong Li Tao Xia Liping Gao 
supported by the joint funds of National Natural Science Foundation of China(Grant Nos.U21A20232,32372756,32072621)。
The members of the fourth subgroup of R2R3-MYB(Sg4 members)are well-known inhibitors of phenylpropanoid and lignin synthesis pathways.The C2 domain is closely related to the transcriptional inhibitory activity of Sg4 ...
关键词：Camellia sinensis Cs MYB4a Phenylpropanoid pathway MAPK YABBY Leaf development 
Electroacupuncture enhances the mitophagy of granulosa cells in premature ovarian insufficiency model mice by inactivating the hippo-yes-associated protein/transcriptional co-activator with postsynaptic density protein,drosophila disc large tumor suppresso
《Journal of Traditional Chinese Medicine》2025年第1期13-21,共9页WU Jiaman TANG Meng LUO Yu ZHU Haimin ZHAO Tianqi MA Fei NING Yan 
Shenzhen Science and Innovation Commission:Investigating the Mechanism of Action of Acupuncture in Regulating the Gut Microbiome to Inhibit Apoptosis of Ovarian Granulosa Cells in Premature Ovarian Insufficiency Mice based on the Rictor/Torepamycin Target Protein c2 Pathway(No.JCYJ20210324130001004);Sanming Project of Medicine in Shenzhen:the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Luo Songping National Famous Chinese Medicine Practitioner Female Reproductive Disorders Prevention and Treatment Team(SZZYSM202311010)。
OBJECTIVE:To investigate the potential mechanism of electroacupuncture(EA)in alleviating premature ovarian insufficiency(POI)and to provide a theoretical basis for EA treatment of POI.METHODS:For this purpose,a POI mi...
关键词：primary ovarian insufficiency acupuncture point CV4(Guanyuan) MITOPHAGY hippo signaling pathway 
Time-Dependent Transcriptional Dynamics of Contextual Fear Memory Retrieval Reveals the Function of Dipeptidyl Peptidase 9 in Reconsolidation
《Neuroscience Bulletin》2025年第1期16-32,共17页Wen-Ting Guo Wen-Xing Li Yu-Chen Liu Ya-Bo Zhao Lin Xu Qi-Xin Zhou 
supported by the STI2030-Major Projects(2022ZD0204900);the National Natural Science Foundation of China(32071029 and 32271080);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32020200);the Yunnan Provincial Science and Technology Department(202402AA310014).
Numerous studies on the formation and consolidation of memory have shown that memory processes are characterized by phase-dependent and dynamic regulation.Memory retrieval,as the only representation of memory content ...
关键词：Transcriptome analysis Temporal gene expression Fear memory retrieval RECONSOLIDATION DPP9 
Evaluating the role of IER3t macrophages in the prognosis of liver fibrosis by bulk and single-cell transcriptional analyses
《iLIVER》2024年第4期32-43,共12页Ling Chu Junbo Zhang Ruoyu Meng Quan Zhuang 
funded by the National Natural Science Foundation of China(82270795);the Wisdom Ac-cumulation and Talent Cultivation Project of the 3rd University Xiangya Hospital of Central South(YX202009).
Background and aims:Liver fibrosis(LF)is the common pathological process of almost all liver diseases,but the pathogenesis is extremely complicated and has not been fully clarified.Therefore,we want to explore LF’s c...
关键词：Liver fibrosis MACROPHAGE IER3 Single-cell RNA sequencing 
FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis
《Acta Pharmacologica Sinica》2024年第11期2313-2327,共15页Ying-quan Wen Zi-yuan Zou Guan-guan Zhao Meng-jiao Zhang Yong-xin Zhang Gai-hong Wang Jing-jing Shi Yuan-yang Wang Ye-yu Song Hui-xia Wang Ru-ye Chen Dong-xuan Zheng Xiao-qun Duan Ya-meng Liu Frank J.Gonzalez Jian-gao Fan Cen Xie 
supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39020600);National Key Research and Development Program of China(2021YFA1301200);National Natural Science Foundation of China(82222071,91957116,82173873);and Project supported by Shanghai Municipal Science and Technology Major Project.
The escalating obesity epidemic and aging population have propelled metabolic dysfunction-associated steatohepatitis(MASH)to the forefront of public health concerns.The activation of FXR shows promise to combat MASH a...
关键词：MASLD/MASH FXR TRANSCRIPTOME gut-liver axis AGONIST 
Nicotine-induced transcriptional changes and mitochondrial dysfunction in the ventral tegmental area revealed by single-nucleus transcriptomics
《Journal of Genetics and Genomics》2024年第11期1237-1251,共15页Lei Fan Boxin Liu Ru Yao Xia Gao Hongjuan Wang Sanjie Jiang Xiaomin Zheng Huan Chen Hongwei Hou Yong Liu Qingyuan Hu 
supported by the Major Project of Tobacco Biological Effects(552022AK0070,110202102014)。
Nicotine is widely recognized as the primary contributor to tobacco dependence.Previous studies have indicated that molecular and behavioral responses to nicotine are primarily mediated by ventral tegmental area(VTA)n...
关键词：Single-nucleus transcriptomics Ventral tegmental area Nicotine addiction Cell-type-specific alteration Mitochondrial dysfunction 
Next-generation research on transcriptional regulation of plant immunity
《Molecular Plant》2024年第11期1651-1653,共3页Akira Mine 
supported by the Grant-in-Aid for Scientific Research(B)(24K01757);the Grant-in-Aid for Challenging Exploratory Research(22K19178).
Plant health is fundamental for agricultural production to feed the growing global population as well as for primary production to sustain ecosystem functions.The innate immune system of plants is integral to their he...
关键词：TRANSCRIPTIONAL plant IMMUNITY 
DDX21 is a new player in co-transcriptional RNA modification and functions
《Science China(Life Sciences)》2024年第10期2291-2293,共3页Chengqi Yi 
supported by the National Key Research and Development Program of China(2023YFC3402200);the Beijing Natural Science Foundation(Z220013);the National Natural Science Foundation of China(91953201)。
Ever since the first discovery of chemical modifications of RNA in 1951,researchers have been captivated by the diverse types of modifications,their associated enzymes and proteins(writers,erasers,or readers),and thei...
关键词：MODIFICATION PLAYER STANDS 
A midgut transcriptional regulatory loop favors an insect host to withstand a bacterial pathogen
《The Innovation》2024年第5期36-45,35,共11页Zhaojiang Guo Liuhong Zhu Zhouqiang Cheng Lina Dong Le Guo Yang Bai Qingjun Wu Shaoli Wang Xin Yang Wen Xie Neil Crickmore Xuguo Zhou RenéLafont Youjun Zhang 
supported by the National Natural Science Foundation of China(32221004,32172458,and 32372600);the China Postdoctoral Science Foundation(2023M733828);the earmarked fund for CARS(CARS-23),the Central Public-interest Scientific Institution Basal Research Fund(Y2024XK01);the Beijing Key Laboratory for Pest Control and Sustainable Cultivation of Vegetables,and the Innovation Program of Chinese Academy of Agricultural Sciences(CAAS-CSCB-202303).
Mounting evidence suggests that insect hormones associated with growth and development also participate in pathogen defense.We have discovered a previously undescribed midgut transcriptional control pathway that modul...
关键词：ELEVATED TRANSCRIPTIONAL LOOP 
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