Transcriptional programs associated with luminal play a vital role in invasive mucinous lung adenocarcinoma  

作　　者：Shufan Zhang Rong Jiang Changguo Wang Manqiu Yang Tao Wang Jianzhou Cui Guangbin Li Shaomu Chen Moli Huang 

机构地区：[1]School of Biology and Basic Medical Sciences,Soochow University,Suzhou,Jiangsu 215123,China [2]Department of Pulmonary and Critical Care Medicine,The First Affiliated Hospital of Soochow University,Suzhou,Jiangsu 215006,China [3]Cambridge-Suda Genomic Research Center,Soochow University,Suzhou,Jiangsu 215123,China [4]Immunology Translational Research Programme,Yong Loo Lin School of Medicine,National University of Singapore,Singapore117456,Singapore [5]Immunology Programme,Life Science Institute,National University of Singapore,Singapore 117456,Singapore [6]NUS-Cambridge Immunophenotyping Centre,National University of Singapore,Singapore 117456,Singapore [7]Department of Thoracic Surgery,The First Affiliated Hospital of Soochow University,Suzhou,Jiangsu 215006,China

出　　处：《Genes & Diseases》2025年第2期21-24,共4页基因与疾病(英文)

基　　金：supported by the National Natural Science Foundation of China (No.32370598,31971117);the National Key R&D Program of China (No.2018YFA0801100);the Natural Science Foundation of Suzhou,Jiangsu,China (No.SYS201517);the Priority Academic Program Development of Jiangsu Higher Education Institutions (China)。

摘　　要：Invasive mucinous lung adenocarcinoma(IMAi)san aggressive subtype characterized by the presence of tumor cells with goblet cell morphology and abundant intracytoplasmic mucin.A previous study had shown that all epithelial tumors share similar gene expression-based luminal/basal subtypes and can impact treatment response.1 We identified the subtype of mucinous adenocarcinoma and found that many of them exhibit a luminal phenotype,particularly IMA.

关 键 词：ADENOCARCINOMA LUMINAL MUCINOUS 

分 类 号：R73[医药卫生—肿瘤]