Inducing Z-DNA overcomes immune checkpoint blockade resistance  

作　　者：Huipeng Jiao Manolis Pasparakis 

机构地区：[1]Institute for Genetics,University of Cologne,Cologne,Germany [2]Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases(CECAD),University of Cologne,Cologne,Germany [3]Center for Molecular Medicine(CMMC),University of Cologne,Cologne,Germany.

出　　处：《Cell Research》2022年第10期871-872,共2页细胞研究（英文版）

摘　　要：Inducing immunogenic cell death in tumors holds promise in stimulating anti-tumor immunity.A recent study published in Nature reported that a small molecule previously shown to induce the formation of Z-DNA activates ZBP1-dependent cell death and renders tumors sensitive to immune checkpoint blockade-based immunotherapy.Cancer immunotherapy by immune checkpoint blockade(ICB)has achieved remarkable success in individual cases;however,these are still restricted to a small number of patients.Therefore,novel approaches to enhance anti-tumor immunity are urgently needed.Induction of immunogenic cell death,such as necroptosis,in tumor cells was shown to synergize with ICB to induce antitumor immune responses in mouse models.1 The RNA-editing enzyme adenosine deaminase acting on RNA 1(ADAR1)has emerged as a novel checkpoint conferring resistance to ICB therapy.

关 键 词：ADAR1 RESISTANCE RENDER 

分 类 号：Q52[生物学—生物化学]