以氢化阿魏酸为假模板制备的印迹聚合物对阿魏酸的识别  

Ferulic Acid-Selective Polymers Prepared by Molecular Imprinting of Hydrogenated Ferulic Acid as Dummy Template

作　　者：朱秀芳[1] 曹秋娥[1] 汪国松[1] 侯能邦[1] 丁中涛[1] 

机构地区：[1]云南大学化学系

出　　处：《分析化学》2006年第U09期118-122,共5页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金(No.30260014;20465003);云南省自然科学基金(No.2003B0004M);云南大学生物制药创新人才基地资助项目

摘　　要：以氢化阿魏酸为假模板分子(dummy template),4-乙烯基吡啶为功能单体,通过自组装技术在乙腈中制备了对阿魏酸具有良好识别能力的印迹聚合物。采用平衡吸附法表征了聚合物在不同吸附条件下对阿魏酸的吸附特性及分子识别性能,并用紫外光谱滴定法和Scachard结合模型研究了聚合物的印迹机理和识别机理。研究表明,该聚合物对阿魏酸的识别能力甚至高于氢化阿魏酸,而且在50%的水溶液仍能有效识别阿魏酸。进一步将该聚合物用于川芎水提液中阿魏酸的提取分离,获得较好结果,显示该聚合物具有直接作为传统中药中阿魏酸分离提取材料的潜能。A selective molecularly imprinted polymer to ferulic acid was prepared in acetonitrile by molecular self-assembly technology using 4-vinylpyridine （4-VP） as monomer and hydrogenated ferulic acid （HFA） as dummy template. The adsorption property and selective recognition ability of the polymer was characterized by equilibrium binding experiments in different adsorption system. The imprinting and recognition mechanisms were studied through ultraviolet photometric titration and Scatchard binding model. The results revealed that the polymer showed better affinity to ferulic acid than hydrogenated ferulic acid, and possessed the peculiar recognition property to be used in 50% water-containing solution. The imprinted polymer was further used as adsorbent of Ligustican Chuanxiong Hort water extract and got satisfying results. The test indicate that the polymer can be used as potential adsorption material to extract ferulic acid directly from traditional Chinese medicines.

关 键 词：分子印迹 阿魏酸 氢化阿魏酸 假模板 

分 类 号：TQ461[化学工程—制药化工]