胃癌组织中转化生长因子α、表皮生长因子受体和增殖细胞核抗原的表达  

Expression of transforming growth factor-α,epidermal growth factor receptor and proliferating cell nuclear antigen in human gastric cancer tissues

作　　者：王春虹[1] 刘丽娜[2] 吕申[3] 

机构地区：[1]本溪市本钢总医院消化内科,辽宁省本溪市117000 [2]大连医科大学附属一院消化内科,辽宁省大连市116011 [3]大连医科大学附属二院中心实验室,辽宁省大连市116023

出　　处：《世界华人消化杂志》2006年第31期3026-3029,共4页World Chinese Journal of Digestology

摘　　要：目的:观察TGF-α,EGFR,PCNA在胃癌组织中的表达,研究三者对胃黏膜上皮细胞增殖的作用及与癌变的关系.方法:采用免疫组织化学SP法分别检测TGF-α,EGFR,PCNA在正常胃黏膜34例、胃癌62例中的表达,分析不同病理组织学分型的TGF-α,EGFR,PCNA表达差异.结果:TGF-α,EGFR,PCNA在正常胃组织阳性表达率均明显低于胃癌组织的阳性表达率(χ2=10.090,P<0.05;χ2=4.373,P<0.05;χ2=31.230,P<0.05).TGF-α,EGFR,PCNA在胃低分化腺癌阳性表达均明显高于高中分化腺癌(χ2=15.290,P<0.05;χ2=7.779,P<0.05;χ2=10.895,P<0.05),低分化腺癌与黏液癌之间阳性表达无显著性差异(P>0.05).胃癌组织中TGF-α与PCNA表达呈正相关(χ2=5.158,P<0.05).胃癌组织中EGFR与PCNA表达呈正相关(χ2=5.322,P<0.05).结论:TGF-α,EGFR和PCNA与胃癌发生相关,可能与胃癌的恶性程度有关,对判断预后有帮助.AIM： To observe the expression of transforming growth factor-α （TGF-α, epidermal growth factor receptor （EGFR） and proliferating cell nuclear antigen （PCNA） as well as their correlations in gastric carcinoma. METHODS： Irnrnunohistochemical staining （SP method） was used to detect the expression of TGF-α, EGFR and PCNA in specimens from 62 gastric carcinoma patients, and the pathological characteristics were comparatively analyzed. RESULTS： The positive rates of TGF-α, EGFR and PCNA expression in normal gastric mucosa were significantly lower than those in gastric carcinoma （χ^2 = 10.090, P 〈 0.05; χ^2 = 4.373, P 〈 0.05; χ^2=31.230, P 〈 0.05）, while their positive expression rate were markedly higher in the lowly-differentiated adenocarcinoma and mu- cosal carcinoma than those in the highly- and moderately-differentiated one （χ^2 = 15.290, P 〈 0.05; χ^2 = 7.779, P 〈 0.05; 2 = 10.895, P 〈 0.05）. A positive correlation was observed between TGF-α and PCNA expression （χ^2 = 5.158, P 〈 0.05） as well as between EGFR and PCNA expression （χ^2= 5.322, P 〈 0.05）. CONCLUSION： The expression of TGF-α, EGFR and PCNA play important roles in the carcinogenesis and progression of gastric carcinoma, and they may help to evaluate the prognosis of gastric cancer patients.

关 键 词：转化生长因子Α 表皮生长因子受体 增殖 细胞核抗原 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]