肺原发性黏膜相关淋巴组织淋巴瘤12例诊断与治疗  

Diagnosis and treatment of primary pulmonary mucosa-associated lymphoid tissue lymphoma

作　　者：徐鹤云[1] 李任远[1] 倪一鸣[1] 王丽君[2] 周建英[3] 

机构地区：[1]浙江大学医学院附属第一医院心胸外科,杭州310003 [2]浙江大学医学院附属第一医院病理科,杭州310003 [3]浙江大学医学院附属第一医院呼吸内科,杭州310003

出　　处：《中华结核和呼吸杂志》2006年第11期755-757,共3页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：目的探讨肺原发性黏膜相关淋巴组织淋巴瘤的临床诊断与治疗方法。方法对1992年8月至2005年5月收集的12例肺原发性黏膜相关淋巴组织淋巴瘤（MALT lymphoma）患者的临床资料、治疗、随访结果进行总结。结果随访6～164个月（平均70．3个月），12例目前均存活。手术治疗6例，术后化疗4例。单纯化疗4例，2例为完全缓解，2例为部分缓解。临床观察2例，带病生存。1例术后12．7年复发，随访8个月生存良好。结论肺原发性黏膜相关淋巴组织淋巴瘤临床表现无特异性，但其胸部放射线检查较为特异，表现为边缘模糊，内有充气支气管征的肿块。该病主要依靠病理组织学及免疫组化诊断。手术治疗结合化疗或者单纯化疗，疗效均较满意，是一种预后相对良好的恶性肿瘤。Objective To study the diagnosis and treatment for primary pulmonary mucosa- associated lymphoid tissue lymphoma. Methods The clinical data of 12 patients with primary pulmonary mucosa-associated lymphoid tissue lymphoma from August 1992 to May 2005 were analyzed. Results All the patients survived during the follow-up periods of 6 to 164 months （mean 70. 3 months）. Gastric mucosaassociated lymphoid tissue lympboma was found to coexist in 2 patients. No specific symptoms or signs, or specific results of broncboscopy, ultrasonography or bone marrow examination were found in these patients, except that radiography showed nodules with blurred margins with characteristic air broncbogram. The final diagnosis was based on histology and immunohistochemistry. Surgical resection was performed for 6 patients, including 5 radical operations and 1 partial resection, among which 4 patients received adjuvant chemotherapy. Recurrence occurred in 1 patient 12. 7 years after the operation, while the other 5 patients got disease free survival. Chemotherapy alone was administered for 4 patients, among whom 2 patients got complete remission and the others got partial remission. The other 2 patients received no treatment and had survived for 6 and 26 months respectively. Conclusions Except for the radiographic findings, there were no specific clinical manifestations for primary pulmonary mucosa-associated lymphoid tissue lymphoma. The final diagnosis should be made by histology and immunohistochemistry. Surgery and chemotherapy can be adopted for the patients with good outcomes.

关 键 词：肺 淋巴瘤 黏膜相关淋巴样组织 

分 类 号：R734.2[医药卫生—肿瘤]