mTOR信号途径与表观遗传关系的研究进展  

Research Advances on the Relationship of PI3-Kinase/Akt/mTOR Pathway and Epigenetic Modification

作　　者：王霞[1] 孙丹凤[1] 房静远[1] 

机构地区：[1]上海交通大学医学院附属仁济医院,上海市消化疾病研究所,上海200001

出　　处：《遗传》2006年第12期1585-1590,共6页Hereditas（Beijing)

基　　金：国家自然科学基金重点项目(编号:30170413);国家重点基础研究发展规划(973计划)项目(编号:2005CB522400)资助~~

摘　　要：mTOR(mammalian target of rapamycin)是雷帕霉素在哺乳动物细胞内作用的蛋白激酶,通过PI3K/Akt信号磷酸化激活而调控细胞分裂、促进转录、信号翻译等,mTOR抑制剂具有抗肿瘤和免疫抑制的潜力,已进入临床II期试验。DNA甲基化可沉默基因转录,组蛋白磷酸化的动态变化主要影响信号传导通路中相关基因的转录,DNA甲基化和组蛋白共价修饰以及RNA干扰技术都是表观遗传修饰的方式,可以调节mTOR信号途径蛋白激酶的表达,激活或抑制mTOR也可以影响DNA甲基化和组蛋白磷酸化等。本文将对mTOR信号途径与表观遗传关系的研究进展作一综述。The mammalian target of rapamycin （mTOR） has been shown to link growth factor signaling and posttranscriptional control of protein translation through activation of the PI3K/Akt pathway, which is frequently involved in cell cycle progression. The inhibition of mTOR has promising potential in anticancer and immunosuppressive therapies, and additional phase Ⅱ clinical trials are ongoing. Epigenetic modification, which involves DNA methylation, histone modification and chromatin remodeling, as well as the recently described RNAi mechanism, can initiate the formation of silenced chromatin. Persistent activation or inhibition of the mTOR pathway may affect epigenetic modification. In this paper, we reviewed the research advances in the relationship between PI3K/Akt/mTOR and epigenetic modification.

关 键 词：MTOR 表观遗传 DNA甲基化 组蛋白修饰 RNA干扰 雷帕霉素 

分 类 号：Q343[生物学—遗传学]