E-Cadherin表达与肝细胞癌侵袭、转移的关系  

RELATIONSHIP BETWEEN E-Cadherin AND INVASION AND METASTASIS OF HEPATOCELLULAR CARCINOMA

作　　者：洪坚善[1] 彭浩[1] 段小娴[2] 曹骥[2] 欧超[2] 杨华伟[1] 

机构地区：[1]广西医科大学附属肿瘤医院胃肠乳腺外科 [2]广西医科大学附属肿瘤医院病理学研究室

出　　处：《广西医科大学学报》2006年第5期699-702,共4页Journal of Guangxi Medical University

基　　金：广西青年科技基金资助项目(No.0229029)

摘　　要：目的:研究上皮性钙黏蛋白(E-Cadherin)在人肝细胞癌(hepatocellular carcinoma,HCC)中的表达情况,探讨其与肝癌侵袭转移的关系。方法:选择56例有完整随访资料的肝细胞癌及相应癌旁组织标本、20例正常肝组织标本,用RT-PCR方法检测E-Cadherin mRNA的表达。结果:①E-Cadherin在肝细胞癌组织中的表达显著低于癌旁组织和正常组织(P<0.05),而在癌旁组织和正常组织中的表达无差异(P>0.05);②E-Cadherin在肝癌组织中的表达与术后复发时间呈正相关(R2=0.887,P<0.05),与病理分级呈负相关(R2=0.823,P<0.05);③癌组织中E-Cadherin表达与肝外转移呈负相关(R2=0.839,P<0.05);④癌旁组织中E-Cadherin表达与肝外转移时间呈正相关(R2=0.861,P<0.05)。结论:E-Cadherin表达与肝细胞癌的分化程度,侵袭转移能力,复发倾向相关,通过检测E-Cadherin表达将对肝细胞癌临床转归的评估有一定指导意义。Objective：To investigate the association between E-Cadherin expression of hepatocellular carcinoma （HCC） and its invasion and metastasis. Methods： RT-PCR analysis technology were used to detect E-Cadherin mRNA expression respectively in 56 paired HCC and non-HCC liver tissue samples and 20 normal liver tissue samples. Result：（1）The level of E-Cadherin expression in HCC was significantly lower than that in adjacent non-HCC liver tissue and in normal liver tissue （ P 〈0.05） ; but no difference was found between adjacent non-HCC liver tissue and normal liver tissue （ P 〉0.05） ; （2）E-Cadherin expression in HCC had a positive correlation with recurrence after surgical treatment （R^2 =0. 887, P 〈0.05） and an inverse correlation with pathological grade （R^2=0. 823, P 〈0.05）; （3）There was an inverse correlation between E-Cadherin expression in HCC and extrahepatic metastasis （R^2 = 0. 839, P 〈0.05） ; （4） Significant positive correlations were found between E-Cadherin expression in adjacent non-HCC liver tissue and extrahepatic metastasis （R^2 =0. 861, P 〈0.05）. Conclusion：E-Cadherin have an correlation with degree of tumor differentiation, capability of invasion and metastasis and tendency of recurrence, which may have some instructive significance for assessment of the outcome of HCC.

关 键 词：上皮性钙黏蛋白 肝细胞癌 侵袭转移 

分 类 号：R735.7[医药卫生—肿瘤]