An Experimental Study on Single and Repeated-dose Administration of Clonazepam （CZP）  

作　　者：Lin Yang Mei Zhao Shaoping Huang 

机构地区：[1]Department of Pediatrics, Second Hospital, Xi＇an Jiaotong University [2]不详

出　　处：《Journal of US-China Medical Science》2005年第4期25-28,共4页美中医学（英文版）

摘　　要：To find a safe and quick way for clinical use of CZP. Sprague-Dawley （SD） rats were divided by comparison of single and repeated-dose administration into single-dose paradigm, repeated-dose paradigm, repeated-dose at different time point paradigm and decreased-dose paradigm. The animals received CZP by intraperitoneal injection. The concentration of CZP in serum and brain were determined by high performance liquid chromatography （HPLC）. In single dose group, the concentration of CZP had decreased rapidly, especially in brain. Repeated administration of CZP after 30 min could maintain a high concentration in serum and brain for a relatively long time. But comparing with the ratio of brain to serum concentration, the ratio of repeated-dose group was higher than that of single-dose paradigm, so the drug would accumulate in the brain with repeated-dose. However, administering CZP by decreased dose could degrade the accumulation, because reducing the second dose of CZP, the ratio of brain to serum concentration was also decreased. Repeated administration of CZP would lead to drug accumulation in the body, especially in the brain, this may be the cause of its toxic effects. But repeatedly giving CZP followed by decreased dose might increase the drug＇s effectiveness in treating without substantially increasing toxicity.

关 键 词：CLONAZEPAM single dose repeated dose 

分 类 号：R96[医药卫生—药理学]