抗癫痫药高敏综合征5例临床报告  

The clinical report of 5 cases of antiepileptic drug hypersensitive syndrome （AHS）

作　　者：姜丹[1] 

机构地区：[1]安徽医学高等专科学校附属医院神经内科,230022

出　　处：《Journal of US-China Medical Science》2005年第3期22-24,共3页美中医学（英文版）

摘　　要：目的总结抗癫痫药高敏综合征（AHS）的临床特点。方法报告5例抗癫痫药高敏综合征。结果5例AHS患者均痊愈出院；其中1例留有轻微四肢震颤，其余4例未见明显不适。结论结合文献，可总结抗癫痫药高敏综合征的患者均有发热、皮疹及内脏损害，部分患者的皮疹表现为Stevens-Johson综合症（SJS）、中毒性表皮松解症（TEN），立即停用致病药物及应用糖皮质激素是治疗的关键。芳香族抗癫痫药（苯妥英钠、笨巴比妥及卡马西平）能导致抗癫痫药高敏综合征。Objective To investigate the clinical charateristics of antiepileptic drug hypersensitive syndrome （AHS）. Methods To report 5 cases of AHS. Results 5 cases of AHS are all curing, 1 case leaves limbs thrill, the others have no indisposition. Conclusion Review literature, AHS is characterised by fever, skin rashes and involvement of the internal organs. Stevens-Johson syndrome （SJS） and toxic epidermal necrolysis （TEN） were observed in some patients. It is important that treatment of these subjects involved stopping administration of the causative drugs, and treatment of prednisolone. AHS is most frequently associated with aromatic antiepileptic drugs, including phenytion, phenobarbital and carbamazepine.

关 键 词：杭癫痫药高敏综合征 苯妥英钠 卡马西平 苯巴比妥 

分 类 号：R742.1[医药卫生—神经病学与精神病学]