康欣胶囊预处理对急性缺血性肾衰的保护作用研究  

The protection to the acute renal failure pretreating by Kanxin capsule

作　　者：王忠[1] 杜建[1] 翁国星[2] 蔡晶[1] 陈旭徵[1] 

机构地区：[1]福建中医学院 [2]福建省立医院

出　　处：《Journal of US-China Medical Science》2005年第2期65-68,共4页美中医学（英文版）

基　　金：福建省卫生厅重点中医药项目（No.3202-802030002）

摘　　要：目的 研究康欣胶囊对大鼠缺血再灌注肾基因谱的影响，从基因水平研究康欣胶囊的作用机理。方法 SD大鼠随机分为不服用康欣胶囊对照组和服用康欣胶囊实验组，康欣胶囊灌胃5周後，建立缺血模型．采用基因芯片检测康欣胶囊对肾相关基因表达情况的影响。结果 肾4，097个相关基因中，康欣胶囊可使370个基因表达下调，390个基因表达上调；其中肾老化基因活性扫描结果为Cy5：893，CyY3：2，184，Ratio：0．411。实验组缺血7d尿素氮为7．20±0．54mmol／l，肌苷为82．70±10．54umol／l，与对照组比较P〈0．05。结论 康欣胶囊对肾相关基因表达具有下调和上调两方面作用，通过下调肾老化基因表达，延缓肾老化，保护肾脏。To evaluate the effects of the Kanxin Capsule with gene-chip on the rat model of renal ischemia and reperfusion. We divided 24 SD rats into two groups at random： The experimental group served with Kanxin capsule and the blank group without Kanxin capsule. The experimental group was fed with Kanxin capsule for 5 weeks. Made the renal failure by the SD rat model of renal ischemia and reperfusion injury and then detected the gene-chip of the right kidney. 370 gene expressed down-regulation and 390 up-regulation in 4, 097 gene. The result of the renal aging gene is Cy5： 893, CyY3： 2, 184, Ratio： 0.411. In the group of the Kanxin capsule, BUN is 7.20±54mmol/1 and Cr is 82.70±10.54umol/l in 7 days of ischemia and reperfusion injury. Compared with the blank group, p 〈 0.05. Kanxin capsule could make gene expression being down-regulation or up-regulation and has the effect on protecting the renal function by regulating the aging gene down.

关 键 词：康欣胶囊 老化基因 缺血再灌注 基因谱 肾功能 

分 类 号：R965.1[医药卫生—药理学]