纳络酮注射液治疗137例肝性脑病的临床疗效观察  

Observation on therapeutic effects of Naloxone Hydrochloride Injection on 137 patients with hepatic encephalopathy

作　　者：王世伟[1] 何平[2] 田文广[1] 何渝[1] 丁静[1] 

机构地区：[1]重庆市第二人民医院传染科,402160 [2]重庆市第二人民医院消化内科,402160

出　　处：《重庆医学》2006年第22期2070-2070,2072,共2页Chongqing medicine

摘　　要：目的探讨纳络酮注射液治疗肝性脑病的临床疗效。方法将137例肝性脑病患者随机分为两组,治疗组在综合基础治疗上加用纳络酮,对照组仅用综合基础治疗。结果治疗组清醒时间明显缩短,差异有统计学意义(P<0.05);Ⅲ、Ⅳ期肝性脑病3d内清醒者,治疗组明显高于对照组,差异有统计学意义(P<0.05);临床有效率治疗组明显高于对照组,分别为95.7%和85.3%,差异有统计学意义(P<0.05)。结论纳络酮是治疗肝性脑病有效的促进清醒的药物。Objective To study the therapeutic effects of Naloxone Hydrochloride Injection on patients with hepatic encephalopathy（HE）. Methods One hundred and Thirty-seven patients with HE were randomly divided into the treatment group and the control group. The former received naloxone on the base of a complex treatment and the latter only received a complex treatment. Resuits The time of awakening was shorter in the treatment group than that in the control group（P〈0.05）. In the treatment group the patients with Ⅲ, Ⅳ HE awakening within 3d were more than the control group（P〈0.05）. The effective rate of the treatment group was higher than that of the control group,distinguishing to 95.7% and 85.3% （P〈0.05）. Conclusion Naloxone Hydrochloride Injection can promote patients with HE awakeming,so it has clinical value in treating patients with HE.

关 键 词：纳络酮 肝性脑病 临床有效率 

分 类 号：R747.9[医药卫生—神经病学与精神病学]