慢性肝病患者网织血小板与血小板参数变化的探讨  

Exploration of the Variation of Reticulated Platelet and Platelet Parameters in Patients with Chronicliver Diseases

作　　者：李加新[1] 叶军[1] 张立新[1] 

机构地区：[1]泰州市人民医院,江苏泰州225300

出　　处：《实用医技杂志》2006年第21期3760-3761,共2页Journal of Practical Medical Techniques

摘　　要：目的:分析慢性肝病患者外周血中网织血小板(RP)与血小板参数的变化,探讨慢性肝病患者血小板变化的原因。方法:血球计数仪对正常人群及肝病患者的外周血血小板进行计数,流式细胞术测定网织血小板占血小板的百分比(RP%)。结果:慢性肝炎患者大血小板比率(P-LCR)高于正常人群(P<0.05);肝硬化患者RP计数和RP%与正常人群比差异有显著性(P<0.01),血小板平均体积(MPV)小于正常人群(P<0.05)。结论:慢性肝炎患者血小板降低与血小板破坏过多有关;肝硬化患者血小板降低与网织血小板生成减少有关。Objective To investigate the incidence and to explorate the reason of the variation of Reticulated Platelet and Platelet parameters in patients with chronic liver diseases. Methods Reticulated Platelet was detected in patients with liver diseases and healthy controls with flow cytometry method. Results The P-LCR in Hepatitis patients was significance higher than that of normal people（P 〈 0. 05 ） ;The RP and RP% with liver cirrhosis（LC） patients were significantly lower than that of normal people（ P 〈0.01 ） ,and the MPV in LC patients were significantly lower than that of normal people（ P 〈 0. 05 ）. Conclusions These findings suggested that the reasons of PLT decrease in patients with chronic liver diseases due to peripheral destruction while the RP reduce might be one of the reasons of PLT decrease with LC patients.

关 键 词：肝炎 肝硬化 网织血小板 血小板 

分 类 号：R575[医药卫生—消化系统]