醋氯芬酸的合成  

Synthesis of Aceclofenac

作　　者：杨静华[1] 甘斌[1] 章雁[1] 程文香[1] 曹振威[1] 

机构地区：[1]湖北省医药工业研究院,武汉430061

出　　处：《中国药师》2006年第12期1113-1114,共2页China Pharmacist

摘　　要：目的:合成醋氯芬酸。方法:以氯乙酸为原料,和苯甲醇进行酯化反应合成氯代乙酸苄基酯,再经缩合、氢解反应制得目标化合物。结果:改进了合成工艺,总收率达到75%,较文献收率提高35%。结论:该方法原料价廉易得,工艺操作简便,适合工业化生产。Objective： To synthesize aceclofenac. Method： Aceclofenac was synthesized from chloroacetic acid and benzyl alcohol by esterification to give henzyl chloroacetate , which subjected to condensation and hydrogenolysis. Result： The synthetic process was improved and total yield was 75%, which was 35% higher than that reported in the literature. Conclusion： The raw materials in this route is cheap. The improved sythesis has advantages of convenient operation and is suitable for industrial production.

关 键 词：醋氯芬酸 非甾体抗炎药 合成 

分 类 号：R914.5[医药卫生—药物化学]