经母腹脐静脉穿刺术在产前诊断中的应用——附40例分析  

Application of transabdominal cordocentesis in prenatal diagnosis

作　　者：侯红瑛[1] 李小毛[1] 尹玉竹[1] 滕奔琦[1] 

机构地区：[1]中山大学附属第三医院妇产科,510630

出　　处：《新医学》2006年第12期783-785,共3页Journal of New Medicine

基　　金：广东省科技计划项目(编号2003C3419);广东省卫生厅基金(编号A2003221)资助

摘　　要：目的：探讨经母腹脐静脉穿刺术在产前诊断中的应用价值及安全性。方法：选择40例有产前诊断指征的妊娠妇女,在B超引导下行经母腹脐静脉穿刺术。结果：1次穿刺成功率为95%(38/ 40),最终取血成功率为98%(39/40)。脐血检查结果为：9号染色体臂间倒位3例,1号染色体多态性2例,21-三体(47,XX,+21)1例,18-三体(47,XY,+18)1例,胎儿巨细胞病毒感染1例。术中3例发生胎心过缓。该组孕妇术后均无出现并发症,亦无发生穿刺并发症相关的胎儿死亡。结论：在B超引导下行经母腹脐静脉穿刺术具有较高成功率,是比较安全、有效的产前诊断方法。Objective： To study the value and the safety of transabdominal cordocentesis in prenatal diagnosis. Methods：Cordocentesis was performed under uhrasound-guide in 40 pregnant women with indications of intrauterine diagnosis, Results ： The suecessful rate of one puncture was 95% （38/40）. The final successful rate of fetal blood sampling was 98% （39/40）. There were 3 cases with chromosome 9 inversion, 2 with chromosome 1 polymorphism, 1 with trisomy 21 （47, XX, ＋ 21 ）, 1 with trisomy 18 （47, XY, ＋ 18） and 1 with intrauterine Cytomegalovirus CMV infection. There was no postoperative complication of cordocentosis in this group of pregnant women, and there was no fetal death with complication of cordoeentesis. Conclusion： Transabdominal cordoeentesis is a safe and effective method for prenatal diagnosis.

关 键 词：脐带穿刺术 脐静脉 超声检查 产前诊断 染色体畸变巨细胞病毒感染 

分 类 号：R714.5[医药卫生—妇产科学]