Testosterone decreases adiponectin levels in female to male transsexuals  

作　　者：Marta Berra Francesca Armillotta Laura D'Emidio Antonietta Costantino Giuseppe Martorana Giuseppe Pelusi MariaCristina Meriggiola 

机构地区：[1]Department of Obstetrics and Gynecology [2]Department of Urology S.Orsola-Malpighi Hospital,University of Bologna,Bologna 40138,Italy

出　　处：《Asian Journal of Andrology》2006年第6期725-729,共5页亚洲男性学杂志（英文版）

摘　　要：Aim： To evaluate the effect of testosterone （T） on adiponectin serum levels in transsexual female patients. Methods： We measured adiponectin, leptin, luteinizing hormone and follicle stimulating hormone, T, estradiol, lipid profile, biochemical parameters and body composition in 16 transsexual female patients at baseline and after 6 months of T treatment （100 mg Testoviron Depot/10 days, i.m.）. Results： Adiponectin levels were 16.9 ± 7.3 mg/mL at baseline and 13.5 ± 7.4 mg/mL at month 6 of T treatment （P 〈 0.05）. Leptin and high-density lipoprotein cholesterol decreased significantly, whereas body mass index, waist circumference and lean body mass increased significantly after 6 months of T treatment. No changes in insulin or Homeostasis Model Assessment were detected. Conclusion： T can significantly reduce adiponectin serum levels in transsexual female patients.Aim： To evaluate the effect of testosterone （T） on adiponectin serum levels in transsexual female patients. Methods： We measured adiponectin, leptin, luteinizing hormone and follicle stimulating hormone, T, estradiol, lipid profile, biochemical parameters and body composition in 16 transsexual female patients at baseline and after 6 months of T treatment （100 mg Testoviron Depot/10 days, i.m.）. Results： Adiponectin levels were 16.9 ± 7.3 mg/mL at baseline and 13.5 ± 7.4 mg/mL at month 6 of T treatment （P 〈 0.05）. Leptin and high-density lipoprotein cholesterol decreased significantly, whereas body mass index, waist circumference and lean body mass increased significantly after 6 months of T treatment. No changes in insulin or Homeostasis Model Assessment were detected. Conclusion： T can significantly reduce adiponectin serum levels in transsexual female patients.

关 键 词：ADIPONECTIN TESTOSTERONE TRANSSEXUALISM 

分 类 号：R96[医药卫生—药理学]