声门上喉癌E-cd和EGFR表达的临床意义  

The clinical significance of the expression of E-cd and EGFR proteins in supraglottic carcinoma

作　　者：王林古[1] 张少强[1] 李随勤[1] 

机构地区：[1]西安交通大学医学院第一附属医院耳鼻咽喉科,陕西西安710061

出　　处：《现代肿瘤医学》2006年第12期1503-1506,共4页Journal of Modern Oncology

摘　　要：目的:探讨表皮钙粘素(E-cadherin,E-cd)和表皮生长因子受体(EGFR)在声门上喉癌的表达及其临床意义。方法:用LSAB免疫组化法,检测了54例声门上型鳞状细胞癌手术切除标本E-cd和EGFR的表达。结果:E-cd的阳性表达(E-cd+)率为44.4%,EGFR的阳性表达(EGFR+)率为53.7%;二者均与肿瘤的TNM分期、浸润范围、淋巴结转移及癌细胞的分化程度有相关性(P<0.01或P<0.05)。E-cd+组的5年生存率为94.29%,E-cd阴性(E-cd-)组的5年生存率为61.53%;EGFR阴性(EGFR-)组的5年生存率为94.74%,EGFR+组的5年生存率为59.06%;E-cd+EGFR-组的5年生存率为100.00%,E-cd-EGFR+组的5年生存率为55.03%;组间差异均有显著性(P<0.01)。临床未发现颈淋巴结转移而术后病理证实有转移的(cNp-N+)5例中4例为E-cd-EGFR+。结论:E-cd和EGFR的表达各自均可作为声门上喉癌侵袭、转移及预后的标志物,如二者结合,则更有预测价值。Objective：To study the expression and clinical significance of E - cadherin （ E - cd） and epidermal growth factor receptor （EGFR） proteins in supraglottic carcinoma. Methods： Using LSAB- immunohistochemical technique, the expression of E - cd and EGFR proteins were investigated in 54 cases of human supraglottic squamous cell carcinoma. Results： The rate of expression was 44.4% in the E - cd （ E - cd ^＋ ） and 53.7% in the EGFR （ EG- FR ^＋ ） ,they significantly correlated with TNM stages, invasive extent, lymph node metastasis and degree of differentiation（P 〈 0. O1 or P 〈 0. 05）. The 5 - year cumulative survival rate was 94.29% in the E - cd ^＋ cases, 61.53% in the E - cd - negative cases（ E - cd - ） ,94.74% in the EGFR - negative cases（ EGFR- ）, 59.06% in the EGFR ^＋ cases, with significant difference（ P 〈 0. 01 ）. The prognosis was significantly poor in E - cd^＋ EGFR^＋ subjects ： the 5 - year cumulative survival rate was 100.00% in the E - cd ~ EGFR^- cases, while it was 55.03% in the E - cd- EG^- FR^＋ cases（P 〈 O. O1 ）. Four of five occult lymph node metastasis （ cN^- pN ^＋ ） were E - cd - EGFR^＋. Conclusion ： These findings suggest that the immunohistochemical determination of expression of E - cd and EGFR proteins in supraglottic carcinoma can be used as the predictors of tumor invasion, lymphatic metastasis and prognoses. If combining them, a more precise prognosis can be obtained. Such a combined technique may be very useful as an indicator for grading the biological malignancy of laryngeal cancer.

关 键 词：喉肿瘤 预后 免疫组织化学 表皮钙粘素 表皮生长因子受体 

分 类 号：R739.65[医药卫生—肿瘤]