大肠癌患者可溶性E-选择素及细胞内黏附分子-1血清水平的临床意义  

Clinical significance of serum levels of sE-selectin and intercellular adhesion molecule-1 in colorectal cancer

作　　者：洪道显[1] 陈火国[1] 陈煜[1] 饶华民[1] 伍红贵[1] 

机构地区：[1]江西省肿瘤医院,江西南昌330006

出　　处：《现代肿瘤医学》2006年第12期1553-1555,共3页Journal of Modern Oncology

基　　金：江西省卫生厅基金资助项目(编号:0303069)

摘　　要：目的:探讨大肠癌患者可溶性E-选择素(sE-selectin)及细胞内黏附分子-1(ICAM-1)血清浓度的临床意义。方法:采用酶联免疫吸附试验(ELISA法)检测98例大肠癌患者E-selectin和ICAM-1的血清浓度,并以16例健康志愿者作为对照。结果:血清ICAM-1浓度在正常、大肠癌未转移(DukesA、B期)、大肠癌转移组中(DukesC、D期)依次升高,分别为:15.9±3.6ng/ml、37.9±5.6ng/ml、57.8±4.3ng/ml;各组间差异显著(P均<0.01)。血清sE-selectin浓度在正常、大肠癌未转移(DukesA、B期)、大肠癌转移组中(DukesC、D期)依次升高,分别为:211.2±22.5ng/ml、304.1±19.7ng/ml、391.3±36.2ng/ml;各组间差异显著(P均<0.01)。血清E-selectin和ICAM-1水平与性别、年龄、肿瘤部位及组织学分级无明显相关(P>0.05)。结论:血清E-selectin和ICAM-1表达水平可在一定程度上反映大肠癌的病理进展及转移情况。Objective：To evaluate the serum concentrations of E - selectin and intercellular adhesion molecule - 1 in colorectal cancer and their clinicopathological significance. Methods： The serum levels of sE - selectin （ serum soluble E- selectin ）and ICAM -1 were measured by enzyme -linked immunosorbent assay（ELISA） in 98 patients with colorectal cancer,16 normal cases were controls. Results：The mean serum levels of E - selectin were 211.2 ± 22.5 ng/ml in normal cases,304.1 ± 19.7 ng/ml in the patients with stages of Dukes A and B,391.3 ± 36.2 ng/ml in the patients with stages of DukesC and D ,there were significant differences among these three groups（ P 〈 0.01 ） o The mean serum levels of ICAM - 1 were 15.9 ± 3.6 ng/ml in normal cases, 37.9 ± 5.6 ng/ml in the patients with stages of Dukes A and B,57.8 ±4.3 ng/ml in the patients with stages of Dukes C and D,there were significant differences among these three groups（P 〈0.01 ） ; sE - selectin and sICAM - 1 had no relation to sex ,age,tumor location and histoligical grades（P 〉 0.05 ）. Conclusion： Serum concentrations of E - selectin and ICAM - 1 may reflect colorectal tumor progression and metastasis.

关 键 词：大肠肿瘤 可溶性E-选择素 细胞内黏附分子-1 

分 类 号：R735.34[医药卫生—肿瘤]