综合干预措施对乳癌患者生存质量的影响  

The effects of comprehensive intervention on quality of life of breast cancer patients

作　　者：何小梅[1] 李卉[1] 向明飞[1] 彭军[1] 

机构地区：[1]四川省肿瘤医院,成都人民南路4段55号610041

出　　处：《中国康复医学杂志》2006年第11期1012-1015,共4页Chinese Journal of Rehabilitation Medicine

基　　金：四川省应用基础研究项目(01SY051-46)

摘　　要：目的:研究肿瘤学、心理学和社会医学相结合的多学科综合干预措施,以提高乳癌患者的生存质量。方法:103例乳癌患者随机分为干预组49例和对照组54例,采用专家指导下的系统抗癌和群体抗癌相结合的方法进行健康干预,而对照组则处于自发康复状态。干预期为2年。干预前后采用EORTC-QLQ-C30改进的生命质量评定量表评价生存患者的生存质量。量表包括一般躯体功能、心理状态、社会家庭功能、一般症状及副反应、特殊症状及副反应以及自我评价6个测量维度。协方差分析比较两组生存质量得分的差异。结果:在控制了时间效应后干预前后两组差值比较中,干预组在一般躯体健康、心理状态及自我评价的差值为4.17±1.87、5.69±4.81、1.72±0.88,提高的程度高于对照组(P<0.05或P<0.01)。在控制了不均衡因素后,干预组的一般躯体健康、心理状态、一般副反应、自我评价的差值是2.546±0.542,5.760±1.276、3.582±0.490、2.028±0.355,提高的程度仍高于对照组(P<0.05或P<0.01)。结论:肿瘤学、心理学和社会医学多学科联合的综合干预措施有助于乳癌患者生存质量的提高。Objective：To investigate the comprehensive intervention of oncology,psychology and sociomedicine to improve the quality of life （QOL） of patients with breast cancer. Method： One hundred and three patients were randomly divided into intervention group（49 people） and control group（54 people）. The health intervention included systemized anti-cancer intervention directed by specialists and the masses anti-cancer intervention, but the control group was in spontaneous convalescence state. The intervention duration lasted 2 years. The QOL of survival patients was estimated by the modified EORTC-QLQ-C30 before or after intervention. The scale measured somatic function, mental status, soeial-famil function ,general symptom-side reaction ,special symptom-side reaction and selfevaluation in six dimension. The variation of QOL was analyzed by the eovarianee.Result： The D-values of both groups before or after intervention were compared. The D-values of somatic function,mental status,self-evaluation were 4.17±1.87,5.69±4.81.1.72±0.88 respectively in intervention group after the time effects were controlled, its＇ increased degree was higher than those in control group （P〈0.05 or P〈0.01）. The D-values of somatic function, mental status, symptom-side reaction, self -evaluation were 2.546±0.542,5.760±1.276,3.580±2.490,2.028±0.355 respectively,in intervention group after the disproportion factors were eontrolled, its＇ increased degree was higher than those in control group（P〈0.05 or P〈0.01）. Conclusion：The muhidiseiplinary comprehensive intervention is helpful to elevate the QOL of patients with breast cancer.

关 键 词：恶性肿瘤 生存质量 综合干预 乳癌 

分 类 号：R737.9[医药卫生—肿瘤]