偏头痛患者事件相关诱发电位的特点  

Characteristics of event-related potentials in patients with migraine

作　　者：彭莉[1] 毛春燕[1] 

机构地区：[1]北京大学人民医院神经内科,北京市100044

出　　处：《中国临床康复》2006年第46期4-6,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:通过测定偏头痛患者早期认知功能障碍的指标P300听觉事件相关诱发电位,分析偏头痛患者的认知功能特点。方法:选择2005-01/12在北京大学人民医院神经内科门诊就诊的偏头痛患者56例,同时选取在本院门诊就诊及进行体检的52名健康人作为正常对照组,均自愿参加观察。采用肌电诱发电位仪检测以上两组观察对象的听觉事件相关诱发电位P300,记录波型中P300的潜伏期和波幅。偏头痛组患者均行头颅MRI检查,观察有无异常。记录患者平均头痛发作频率、持续时间、头痛强度和头痛发作史,分析以上指标与听觉事件相关诱发电位P300潜伏期和波幅的相关性。结果:偏头痛组56例患者及正常对照组52名健康人全部进入结果分析,无脱落。①两组观察对象听觉事件相关电位P300的潜伏期和波幅比较:偏头痛组患者P300的潜伏期显著长于正常对照组眼(328.66±33.06,315.73±25.19)ms(t=-2.296,P<0.05)演,波幅显著低于正常对照组眼(11.17±2.05,11.99±1.71)μV(t=2.275,P<0.05)演。②偏头痛组头部MRI检查正常与异常患者听觉事件相关电位P300的潜伏期和波幅比较:56例偏头痛患者中25例异常,表现为皮质下脑白质病变,设为MRI检查异常组;其余31例设为MRI检查正常组。MRI检查异常组患者P300的潜伏期显著长于MRI检查正常组眼(349.88±17.07,311.55±33.06)ms(t=-5.597,P<0.01)演,波幅显著低于MRI检查正常组眼(9.61±1.08,12.42±2.05)μV(t=7.355,P<0.01)演。③偏头痛患者病程与听觉事件相关电位P300的潜伏期呈正相关(P<0.01),与波幅呈负相关(P<0.01)。结论:偏头痛患者存在脑认知功能障碍,且认知障碍程度与病程长短有关,病程越长,程度越重。偏头痛患者可出现脑白质区病变,此病变加重了认知功能障碍。AIM： To investigate the characteristics of cognitive function of patients with migraine by detecting P300 auditory event-related potential, the index of early cognitive handicap of patients with migraine. METHODS： Totally 56 patients with migraine from the outpatient service of Department of Neurology, People＇s Hospital, peking University from January to December 2005 were selected; meanwhile, 52 healthy persons performing physical examination in the hospital were selected as normal control group, they all join the observation voluntarily. Latency and amplitude of P300 of the subjects were measured by myoelectric evoked potential meter. All the patients were detected with MRI of cranium to record their average frequency, persistence time, intensity and course of the disease and analyze the correlation of those indexes with latency and amplitude of P300. RESULTS： The 56 patients of the migraine group and 52 healthy persons of the control group were all involved in the result analysis without any loss. ① Comparison of latency and amplitude of P300 in the two groups： Latency of P300 of the migraine group was longer than the control group [（328.66±33.06, 315.73±25.19） ms, t=-2.296, P 〈 0.05]; but the amplitude was lower than the control group [（11.17±2.05, 11.99±1.71） μV, t=2.275, P 〈 0.05]. ② Comparison of latency and amplitude of P300 in patients with normal and abnormal MRI：25 patients of abnormal MRI of cranium showed leukodystrophy were regarded as abnormal MRI group; the rest cases as normal MRI group. The latency of the patients of abnormal MRI group was significantly longer than the normal MRI group [（349.88±17.07, 311.55±33.06） ms, t=-5.597, P 〈 0.01], but the amplitude was lower than the normal MRI group [（9.61±1.08, 12.42±2.05） μV, t=2.275, P 〈 0.01]. ③ The course of disease was positively correlated with the latency of P300 （P 〈 0.01）, and negatively correlated with the amplitude （P 〈 0.01）. CONCLUSION： Patients with migraine have cog

关 键 词：偏头痛 事件相关电位 P300 认知障碍 

分 类 号：R747.2[医药卫生—神经病学与精神病学]