米非司酮对早孕绒毛组织中细胞间黏附分子-1和血管细胞黏附分子-1表达的影响  

The effect of mifepristone on the expression of ICAM-1 and VCAMA-1 in chorionic villi in early pregnancy abortion women

作　　者：宋月轻[1] 闫晓娟[1] 王健[1] 秦姗[1] 于红健[2] 

机构地区：[1]河北医科大学第三医院妇产科,石家庄市050051 [2]石家庄市妇幼保健院

出　　处：《河北医药》2006年第10期912-913,共2页Hebei Medical Journal

摘　　要：目的探讨米非司酮对早孕绒毛组织中细胞间黏附分子-1(ICAM-1)和血管细胞黏附分子-1(VCAM-1)表达的影响。方法采用免疫组化染色测定绒毛组织中ICAM-1和VCAM-1的表达,其中正常早孕人工流产组20例,米非司酮药物流产组22例。结果ICAM-1和VCAM-1在正常早孕绒毛组织中阳性表达率为80%、75%,在米非司酮药物流产组中阳性表达率为45%、41%,两者差异有显著性(P<0.05)。结论ICAM-1和VCAM-1与胚胎着床及维持正常早孕有关。米非司酮引起ICAM-1和VCAM-1的表达降低可能是抗早孕终止妊娠机制之一。Objective To investigate the effects of mifepristone on the expression of intercellular adhesion molecule-1 （ICAM-1） and vascular cell adhesion molecule-1 （VCAM-1） in chorionic villi in early pregnancy abortion women. Methods The expression of ICAM-1 and VCAM-1 in chorionic villi in 20 early pregnancy abortion women and 22 cases of mifepristone-induced abortion were tested by immunohistechemical technique. Results There were significant differences in the expressions of ICAM-1 and VCAM-1 （80%, 75% vs 45%, 41%） in early pregnancy and mifepristone-induced abortion women （P 〈 0.05）. Conclusion ICAM-1 and VCAM-1 may be associated with embryo implantation and early pregnancy maintenance. One of the mechanisms of mifepristone-induced abortion may be the decrease of the expression of ICAM-1 and VCAM-1 in chorionic villi in early pregnancy abortion women.

关 键 词：米非司酮 绒毛 细胞间黏附分子-1 血管细胞黏附分子-1 

分 类 号：R743.31[医药卫生—神经病学与精神病学]