卡拉胶/纳米羟基磷灰石/胶原可注射骨修复材料的制备与表征  

Preparation and Characterization of a New Injectable Bone Substitute-carrageenan/nano-hydroxyapatite/collagen

作　　者：甘少磊[1] 冯庆玲[1] 

机构地区：[1]清华大学材料科学与工程系,北京100084

出　　处：《中国医学科学院学报》2006年第5期710-713,共4页Acta Academiae Medicinae Sinicae

基　　金：高等学校博士科点专项科研基金(20030003031)~~

摘　　要：目的制备一种新的可注射骨修复材料卡拉胶/纳米羟基磷灰石/胶原(nHAC/Carr),并进行表征。方法将纳米羟基磷灰石/胶原(nHAC)微粒分散在卡拉胶中。结果nHAC/Carr与nHAC的X射线衍射谱无明显差别,可注射材料保持了nHAC的特性。nHAC/Carr的红外光谱显示卡拉胶的化学结构未发生变化。流变性能测试显示nHAC/Carr具有与卡拉胶相似的水凝胶特性。扫描电镜照片和孔隙率分析表明nHAC/Carr材料具有多孔结构,孔隙率在90%左右。结论可注射材料nHAC/Carr有望被用作骨修复材料。Objective To develop a new injectable biomaterial carrageenan/nano-hydroxyapatite/collagen （nHAC/Carr） for bone surgery and characterize it. Methods nHAC/Carr was developed by firing carrageenan with nano-hydroxyapatite/coRagen （nHAC） granules. Results It was found that nHAC/Carr had similar X-ray diffraction patterns with that of nHAC. Fourier transform infrared spectroscopy showed that carrageenan did not change its structure in nHAC/Carr. The rheological behavior of nHAC/Carr was the same as carrageenan. The scanning electron microscopy and porosity analysis showed that nHAC/Carr had porous structure and its porosity was about 90%. Conclusion The biomaterial nHAC/Carr may be used as an injectable bone substitute.

关 键 词：骨修复 卡拉胶 纳米羟基磷灰石/胶原 可注射 

分 类 号：R318.08[医药卫生—生物医学工程]