基因多态性与脑卒中关联研究  

The Association Study Between Stroke and Gene Polymorphism

作　　者：尚蔚[1] 吴晓东[1] 

机构地区：[1]中国科学院生院生物系,北京100039

出　　处：《中国分子心脏病学杂志》2003年第6期371-376,共6页Molecular Cardiology of China

摘　　要：脑卒中属多基因病范畴,遗传方式不遵循单基因病孟德尔遗传的一般规律,难以用一般的家系遗传连锁分析取得突破。分子生物学理论和技术的发展以及人类基因组计划的完成,单核苷酸多态(Single Nucleotide Polymorphism, SNP)与疾病的关联分析方法被广泛用于寻找复杂多基因病-脑卒中的易感基因,并进行发病机理的研究。根据基因具有的不同生物学作用,分类综述目前国内外已经报道的几十种与脑卒中相关的基因多态,以期对脑卒中的致病基因研究有更全面的了解。Stroke is one of polygenlc disorders which genetic basis is unclear. General linkage analysis based on families was unfit for it. Aeeompanied with the development of the theory and technology of molecular biology and the accomplishment of human genome project, the association study between complex genetie illnesses and single nueleotide polymorphism （SNP） were widely used for identifying gene loci which are related to stroke and investigating the mechanism of disease. The present study reviewed more than twenty genes that had been observed to associate with stroke in the world and classed tllem into different groups depending on their biologic roles.

关 键 词：脑卒中 基因多态性 表型 相关 

分 类 号：R743.3[医药卫生—神经病学与精神病学]