超选择动脉插管与导管药盒系统化疗对中晚期宫颈癌疗效的对比研究  

Comparison of therapeutic effects of transcatheter arterial chemoembolization and implantable port system on locally intermediate or advanced cervical cancer

作　　者：石珍[1] 蔡丽萍[1] 辜斌[1] 李敏[1] 邹璐[1] 

机构地区：[1]南昌大学第一附属医院,南昌330006

出　　处：《江西医药》2006年第10期719-723,共5页Jiangxi Medical Journal

摘　　要：目的探讨植入式导管药盒化疗与髂内动脉插管介入化疗对中晚期宫颈癌的疗效。方法中晚期宫颈癌患者81例,随机分为动脉药盒组(PCS)(治疗组)和介入栓塞组(TACE)(对照组),手术或放疗前分别给予PCS和TACE化疗。结果(1)治疗组和对照组病人近期临床总有效率分别为90.0%、70.73%;手术率分别为85.0%、65.85%;骨髓抑制和胃肠道毒副反应分别为37.5%、67.3%和61.0%、87.8%;治疗费用及住院时间两组比较,差异有统计学意义(P<0.05)。(2)两组病人复发率及生存率分别比较,差异无统计学意义(P>0.05)。结论PCS栓塞化疗治疗中晚期宫颈癌近期有效率明显提高,毒副作用减少,具有广阔的应用前景。Objective To explore the therapeutic effects of transcatheter arterial chemoembolization （TACE） and implantable port system （PCS） on locally intermediate or advanced cervical cancer. Methods 81 patients with locally intermediate or advanced cervical cancer were randomly divided into two groups： 40 cases of study group with PCS and 41 cases of control group with TACE. Results （1） The effective rate of PCS group was 90.0%, and the rate of surgery after chemotherapy was 85.0%. while in the TACE group, they were 70.73% and 65.85% respectively. In PCS group, bone marrow depression and digestive tract reaction were 37.5%, 67.3% respectively, and those of TACE group were 61.0%, 87.8% respectively. All differences of the total cost and time in hospital between these two groups showed significance （P〈0.05）. （2）When compared with the relapse rates and survival rates of these two groups, both of them without significant difference （P〉0.05）. Conclusion Compare with TACE, PCS can improve the therapeutic effects and reduce the adverse effects. It＇s a safe and effective means for treating patients with locally intermediate or advanced cervical cancer, and opens up a bright prospects in Neoadjuvant intra-arterial chemotherapy.

关 键 词：宫颈癌 新辅助动脉化疗(NIC) 超选择动脉插管化疗(TACE) 植入式导管药盒系统(PCS) 

分 类 号：R737.33[医药卫生—肿瘤]