蛋白质缺乏在低硒高锰条件下对心肌的损伤作用  

Experimental study of myocardial lesion induced by protein deficiency under low Se and high Mn condition in rats

作　　者：曾宪惠[1] 周葆初[1] 迟月明[1] 刘红[1] 万汇娟[1] 刘立志[1] 刘秀丽[1] 于敬海[1] 刘阳[1] 许立庆[1] 徐柏芬[1] 

机构地区：[1]哈尔滨医科大学克山病研究所

出　　处：《中国地方病学杂志》1996年第6期330-333,共4页Chinese Jouranl of Endemiology

基　　金：国家自然科学基金

摘　　要：用低硒，低硒低蛋白质，低硒低蛋白质高锰半会成饲料喂大鼠。８周后处死。实验结果表明．低硒低蛋白质饲料使动物体重下降，心肌电镜所见，心肌细胞内水肿及少数线粒体空泡变，全血、心肌和肝脏ＧＳＨ－Ｐｘ活性下降、心肌ＣＣＯ初ＳＤＨ活性也有下降趋势。而低硒高锰和蛋白质缺乏的复合作用导致体重明显下降，电镜下显示心肌细胞内水肿，线粒体肿胀、弥漫空泡变，肌原纤维断裂、肌丝分解、全血、肝脏ＧＳＨ－ＰＸ活性和心肌ＣＣＯ、ＳＤＨ活性与低硒低蛋白质组比较明显下降。According to the level of selenium(Se), Manganese(Mn) and protein in diet, Wistar rats were randomly divided into 3 groups: Group A (low Se and normal Mn,protein);group B(low Se,protein and normal Mn) ;group C(low Se,protein and high Mn). The animals were sacrificed after 8-week feeding. The results showed that edematous myocardial cells and degenerative vacuolaris of a few cardiac mitochondria were observed in group B,under electron microscope. The activity of GSH-Px in blood,heart and liver in group B was apparently lower than that of group A. The activity of CCO and SDH in cardiac mitochondria showed a decreasing tendency in group B. But edematous myocardia.cells, extensive degenerative vacuolaris of the cardiac mitochondria,interupt of myofibril and dissolution of myofilaments were observed in group C under electron microscope. The activity of GSH-Px in blood and liver and the activity of CCO and SDH in group C was apparently lower than that in group B.

关 键 词：蛋白质缺乏 硒 锰 心肌损伤 克山病 

分 类 号：R591.2[医药卫生—内科学] R542.3[医药卫生—临床医学]