^(99m)Tc-MIBI联合^(99m)Tc-HL91乏氧显像对60例原发性肺癌的诊断评价  

The diagnostic value of ^(99m)Tc-MIBI combined with ^(99m)Tc-HL91 hypoxia imaging in primary lung cancer

作　　者：张金山[1] 吴兆红[2] 邓咏梅[1] 李敏[1] 林炎彬[1] 黄桂敏[1] 

机构地区：[1]广州医学院第三附属医院核医学科,510150 [2]广州医学院第三附属医院心胸外科,510150

出　　处：《国际放射医学核医学杂志》2006年第5期287-289,共3页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：广州市医药卫生科技资助项目(2004-37)

摘　　要：目的探讨^(99m)Tc-甲氧基异丁基异腈(^(99m)Tc-MIBI)肺亲肿瘤显像联合^(99m)Tc-4,9-二氮- 3,3,10,10-四甲基十二烷-2,11-二酮肟(^(99m)Tc-HL91)乏氧显像对原发性肺癌的诊断效能。方法对60例拟诊断原发性肺癌患者,术前进行^(99m)Tc-MIBI及^(99m)Tc-HL91显像,以病理结果为金标准,分析^(99m)Tc-MIBI联合^(99m)Tc-HL91显像对原发性肺癌的诊断价值。结果病理结果证实原发性肺癌48例,良性病变12例。^(99m)Tc-MIBI、^(99m)Tc-HL91和^(99m)Tc-MIBI+^(99m)Tc-HL91显像对原发性肺癌诊断的灵敏度、特异度和准确率分别为89．6%(43/48)、77．1%(37/48)、95．8%(46/48),75．0%(9/12)、91．7%(11/12)、83．3%(10/12)和86．7%(52/60)、80．0%(48/60)、93．3%(56/60)。结论^(99m)Tc-MIBI肺亲肿瘤显像联合^(99m)Tc-HL91乏氧显像有助于提高对原发性肺癌的诊断效能。Objective To assess the diagnostic value of ^99m Tc-sestamibi （^99m Tc-MIBI）combined with ^99m Tc- labeled 4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime （^99m Tc-HL91） hypoxia imaging in primary lung cancer. Methods 60 patients with suspicious lung tumours underwent ^99m Tc-MIBI and ^99m Tc- HL91 imaging before operation. The diagnosis were confirmed with pathological study after surgeries. The diagnostic effectiveness of ^99m Tc-MIBI and ^99m Tc-HL91 in primary lung cancer were analyzed. Results 48 patients were found primary lung cancer with pathological study, other 12 patients were benign. The sensitivity, speccifity and accuracy obtained with ^99m Tc-MIBI, ^99m Tc-HL91 imaging and the combination of two methods were 89.6%（43/48）, 77.1%（37/48）, 95.8%（46/48）; 75.0%（9/12）, 91.7%（56/60）, 83.3%（10/12） and 86.7%（52/60）, 80.0%（48/60）, 93.3%（56/60）, respectively. Conclusion The combination of ^99m Tc-MIBI and ^99m Tc-HL91 hypoxia imaging may increase the the diagnostic effectiveness in primary lung cancer.

关 键 词：肺肿瘤 体层摄影术 发射型计算机 单光子 ^99m Tc-甲氧基异丁基异腈 ^99m TC-HL91 

分 类 号：R734.2[医药卫生—肿瘤]