泛素连接酶hHrd1在人乳腺癌组织表达的意义  

SIGNIFICANCE OF AN UBIQUITIN LIGASE hHRD1 EXPRESSED IN HUMAN BREAST CARCINOMA

作　　者：吕正梅[1] 贾友苏[1] 王盛花[1] 方圣云[2] 吴强[3] 

机构地区：[1]安徽医科大学组织学与胚胎学教研室,合肥230032 [2]安徽医科大学神经生物学教研室,合肥230032 [3]安徽医科大学病理解剖学教研室,合肥230032

出　　处：《解剖学报》2006年第6期681-684,共4页Acta Anatomica Sinica

基　　金：安徽省高等学校青年教师科研资助计划项目(2003jq125)

摘　　要：目的探讨一种泛素连接酶hHrd1在人乳腺癌发病中的病理意义。方法应用免疫组织化学SP法研究正常人乳腺组织、乳腺增生症、乳腺纤维腺瘤、原发性乳腺癌组织中hHrdl的表达。结果人乳腺癌组织hHrd1蛋白表达水平明显强于正常人乳腺组织、乳腺增生症、乳腺纤维腺瘤。导管内癌(或伴早浸)与浸润性导管癌相比,表达水平低,差异有显著性意义(P<0.05)。人乳腺浸润性导管癌组织hHrd1表达与肿瘤大小有关(P<0.05),与组织学分级、淋巴结是否转移无关(P>0.05)。结论泛素连接酶hHrd1参与人乳腺癌的发生。Objective To carcinogensis. Methods By using investigate the pathological significance of an ubiquitin ligase hHrd1 involved in human breast SP method, the expressions of hHrd1 protein were determined in normal human mammary epithelium, mammary hyperplasia, fibroadenoma and primary carcinoma of breast. Results Expression level of hHrd1 protein was significantly higher in human breast carcinoma than that in normal human mammary epithelium, mammary hyperplasia and fibroadenoma of breast. There was also significant difference between duetal carcinoma in situ （or with early infiltration） and invasive duetal carcinoma （ P 〈 0.05）, and the former was weaker. The expression level of hHrdl correlated positively with tumor size （P 〈 0.05 ）, but not with histologie grade and lymph node metastasis （P 〉 0.05 ）. Conclusion An ubiquitin ligase hHrd1 may play a role in carcinogenesis in human breast.

关 键 词：泛素连接酶 hHrd1 乳腺癌 内质网相关降解 免疫组织化学 人 

分 类 号：R735.7[医药卫生—肿瘤]