亚甲基四氢叶酸还原酶基因多态性与宫颈癌易感性  

Relationship between Methylenetetrahydrofolate reductase polymorphism and cervical cancer susceptibility

作　　者：马晓晨[1] 王金桃[2] 周溱[2] 丁玲[2] 程玉英[3] 王志敏[2] 弟娟娟[2] 

机构地区：[1]北京市疾病预防控制中心,100013 [2]山西医科大学公共卫生学院流行病学教研室 [3]山西省肿瘤医院

出　　处：《中国公共卫生》2006年第12期1427-1428,共2页Chinese Journal of Public Health

摘　　要：目的探讨山西省人群亚甲基四氢叶酸还原酶（MTHFR）基因C677T多态性与宫颈癌易感性的关系。方法采用以医院为基础的病例对照研究，调查111例病理确诊的宫颈鳞状细胞癌和111例子宫肌瘤对照可能危险因素的暴露情况，聚合酶链限制性长度多态性的（PCR-RFLP）方法检测MTHFR基因多态性；多因素Logistic回归模型进行危险因素的分析。结果多因素分析结果显示，677TT基因携带者患宫颈癌的危险是677CC型个体的3．29倍（OR=3．29。95％CI=1．33～8．16），是C等位基因（CC＋CT）携带者的2．74倍（OR=2．74，95％CI=1．31～5．74）。结论MTHFR基因C677T多态性可能是宫颈癌发生的易感因素，携带677TT基因型的个体患宫颈癌的危险明显增加。Objective To explore the Municipal relationship between the MTHFR polymorphism and cervical cancer susceptibility. Methods The hospital - based case - control study was carried out, the risk factors of 111 cases with cervical cancer by pathological diagnosis and 111 patients with hysterteromyoma were investigated, MTHFR C677T polymorphism was analyzed by PCR - RLFP. Logistic regress was used to perform the risk factors analysis. Results The variated genotype of MTHFR increase the risk of cervical cancer , adjusted odds ratio computed for T/T versus C/C was 2.91（95 % （71 = 1.09 - 7.75）, adjusted odds ratio computed for TT/non - T/T was 2.58 （95 % CI = 1.22 - 5.45）, Conclusion The mutant type homozygote of MTHFR C677T was a risk factor of cervical cancer, The risk of cervical cancer increased in women who had MTFHR677TT gene type.

关 键 词：宫颈癌 5 10-亚甲基四氢叶酸还原酶 基因多态性 

分 类 号：R737.33[医药卫生—肿瘤]