不同致癌物对小鼠肺脱氧核糖核酸氧化损伤的影响  

Effect of different carcinogens on the oxidative damage in lung DNA of mice

作　　者：金长炼[1] 王明耀[1] 宋方隆 

机构地区：[1]延边大学医学院

出　　处：《延边医学院学报》1996年第4期210-212,共3页Journal of Medical Science Yanbian University

摘　　要：本文探讨了二甲基亚硝胺、４－甲基亚硝胺－［１－３－吡啶］－正丁酮和苯并芘对Ａ／Ｊ小鼠肺脱氧核糖核酸氧化损伤产物８－羟基－２＇－脱氧鸟苷水平的影响，结果表明，染毒后０．５ｈ，三种致癌物均致小鼠肺脱氧核糖核酸的８－羟基－２＇－脱氧鸟苷水平提高（Ｐ＜０．０１），１ｈ时二甲基亚硝胺和苯并芘组８－羟基－２＇－脱氧鸟苷水平恢复正常，而４－甲基亚硝胺－［１－３－吡啶］－正丁酮组２ｈ仍未恢复正常。In this study we examined the levels of 8-hydroxydeoxyguanosine (8-OHdG)in the A/J mouse lung DNA caused by N-nitroso-dimethylamin (NDMA).4-(metylnitrosamine)-l-(3-pyidy)-butanone (NNK) and benzo (a) pyrent (BaP) treatment.The results showed that the levels of 8-OHdG significantly increased in all animals treated with carcinogens sacrificed at 0.5 h time points. Comparing to NDMA and BaP, higher level of 8-OHdG persisted longer in the lung DNA of the mice treated with NNK.

关 键 词：致癌物 脱氧核糖核酸 肺肿瘤 小鼠 

分 类 号：R730.231.1[医药卫生—肿瘤] R734.202[医药卫生—临床医学]