甲状腺癌中CD_(44)V6和基质金属蛋白酶-2的表达  

Expression of CD_(44)V6 and MMP-2 in human thyroid carcinoma

作　　者：王化修[1] 李景和[2] 

机构地区：[1]邵阳医学高等专科学校病理教研室,湖南邵阳422000 [2]中南大学湘雅医学院病理学系,湖南长沙410078

出　　处：《中国现代医学杂志》2006年第22期3421-3423,共3页China Journal of Modern Medicine

基　　金：湖南省卫生厅科研基金资助(编号:B2005-122)

摘　　要：目的研究黏附分子CD_(44)V6、基质金属蛋白酶-2(MMP-2)在甲状腺癌中的表达、相互关系及其与甲状腺癌侵袭转移的相关性。方法应用S-P免疫组化染色法检测82例甲状腺乳头状癌(PTC)中CD_(44)V6和MMP-2表达。结果82例甲状腺乳头状癌(PTC)中CD_(44)V6和MMP-2阳性表达率为67.1%和68.3%,均高于甲状腺腺瘤周围正常甲状腺组织,P<0.01。CD_(44)V6和MMP-2阳性表达与淋巴结转移呈正相关,P<0.05,且随侵袭程度增加而升高。结论CD44V6、MMP-2在促进甲状腺癌的浸润与转移中呈协同效应,CD_(44)V6和MMP-2表达的综合检测对甲状腺癌转移趋势和预后评估具有重要的参考价值,可能是甲状腺癌侵袭转移、预后判断的分子标志。[Objective] To investigate the correlation between the expression of CD44V6,MMP-2 and invasion, metastasis in thyriod carcinoma. [Methods] The SP immunohistochemical method was employed to detect the expression of CD44V6 and MMP-2 in 82 cases thyroid papillary carcinomas （PTC）. [Results] The positive rate of CD44V6 and MMP-2 was 67.1% and 68.3% respectively in PTCs, both of which was significantly higher than that in the tissues adjacent to thyroid adenomas （P 〈0.01）. Overexpressions of CD44V6 and MMP-2 in PTCs was related to lymph node metastasis（P 〈0.05）. The positive expression of CD44V6 and MMP-2 had a rising tendency with the advancing invasion. [Conclusion] The expression of CD44V6 and MMP-2 is of common effects in invasion and metastasis. To detect the expression of CD44V6 and MMP-2 is of great value, they are related to the diagnoses, differentiation and metastasis of thyroid carcinoma and may be molecular markers to value the invasion and metastasis.

关 键 词：甲状腺癌 CD44V6 基质金属蛋白酶-2 

分 类 号：R736.1[医药卫生—肿瘤]