高压氧对实验性大鼠血栓栓塞性脑梗死出血性转换的影响  

The effect of HBO on hemorrhagic transformation in rats with cerebral infarction embolized by autologous blood clot

作　　者：李长春[1] 杨鹰[2] 魏东风[1] 石永亮[2] 

机构地区：[1]海军潜艇学院防救系,青岛266071 [2]青岛解放军第四○一医院

出　　处：《中华航海医学与高气压医学杂志》2006年第4期222-224,共3页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的研究高压氧对急性脑梗死并发脑出血的影响。方法用自体血栓法制作大鼠大脑中动脉栓塞(MCAO)模型,用SD大鼠36只,随机分成3组:手术对照组、常氧高氮组、高压氧(HBO)治疗组。观察HBO对脑梗死出血转换发生率的影响。结果脑梗死转换出血的自然发生率为33．3％,常氧高氮组的发生率为25．0%,高压氧组为33．3％,高压氧组与手术对照组及常氧高氮组相比出血率无明显提高(P>0．05)。结论高压氧对大鼠血栓性脑梗死出血性转换的发生率无明显的影响。Objective To study the effect of HBO on hemorrhagic transformation （HT） in rats with cerebral infarction embolized by autologous blood clot. Methods The middle cerebral artery （ MCA） embolism model was established in Sprague-Dawley （SD） rats by single autologous blood clot. Thirty-six rats with embolic stroke were divided into 3 groups randomly： the operation control group, the normoxic hyperbaric nitrogen group, and the hyperbaric oxygen group. The effect of HBO on the rate of HT was examined. Results The rate of HT in the three groups were 33.3% , 25.0% and 33.3% , respectively. There was no significant difference among the groups （ P 〉 0.05 ）. Conclusions HBO had no obvious effect on HT in rats with cerebral infarction embolizod by autologous blood clot.

关 键 词：急性脑梗死 出血性转换 高压氧 

分 类 号：R743.3[医药卫生—神经病学与精神病学]