Angiopoietins/Tie-2 expression and angiogenesis in stomach carcinoma  

作　　者：Zhenzhen Zhang Sheng Zhang Jianyin Lin Peisheng Huang Yupeng Chen 

机构地区：[1]Department of Pathology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China [2]Department of Molecular Biology, Fujian Medical University, Fuzhou 350005, China [3]Department of Pathology, Fujian Medical University, Fuzhou 350005, China

出　　处：《The Chinese-German Journal of Clinical Oncology》2006年第6期391-395,共5页中德临床肿瘤学杂志（英文版）

基　　金：Supported by a grant from the Natural Sciences Foundation of Fujian (No. C0110013).

摘　　要：Objective： To explore angiopoietins （Ang-1, Ang-2）/Tie-2 expression and angiogenesis in stomach carcinomas. Methods： RT-PCR and immunohistochemistry were used to detect angiopoietins/Tie- 2 mRNA and protein expression in stomach carcinomas and their adjacent normal mucosa. Microvessel density （MVD） was counted according to CD34 immunohistochemical staining. Results： There was positive expression of Angiopoietins/Tie-2 mRNA and protein in stomach carcinomas and their paired adjacent normal mucosa. It was found that correlation between Ang-1 protein, Tie-2 mRNA expression and MVD was negative （F=-0.440, F=-0.267; P〈0.05）, while the correlation between Ang-2 mRNA and its protein, Ang-2/Ang-1 protein ratio and MVD was positive （F=0.319, F=-729, F=739; P〈0.05）. Moreover, MVD in groups with Ang-2 mRNAT/N ratio over 1.2 （the ratio of Ang-2 mRNA in stomach carcinoma to its adjacent normal mucosa） was higher than those with the ratio under 1.2. Conclusion： It was suggested that Ang-1 and Ang-2 antagonizes in the angiogenesis and the anglogenesis in tumor ultimately depended on Ang-2/Ang-1 ratio, once the expression of Ang-2 is higher than Ang-1 in some degree, the angiogenesis in tumors was promoted, otherwise oppositely. In other words, Ang-2 plays dominant role in the action of angiogenesis in tumors.

关 键 词：angiopoietins （Ang-1 and Ang-2） TIE-2 stomach neoplasm 

分 类 号：R735.2[医药卫生—肿瘤]