乙肝病毒前S1抗原检测在乙型肝炎向肝癌演变中的临床意义  

Determinations of PreS1 antigen in patients with hepatitis B and its clinical significance in tumorigenesis in primary hepatic cancer

作　　者：陈海蔚[1] 伍勇[1] 陈道瑾[2] 

机构地区：[1]中南大学湘雅三医院检验科,湖南长沙410003 [2]中南大学湘雅三医院普外科,湖南长沙410003

出　　处：《实用肿瘤杂志》2006年第6期508-511,共4页Journal of Practical Oncology

摘　　要：目的探讨前S1抗原与原发性肝癌(PHC)的关系。方法采用EL ISA法检测302例PHC患者的血清学乙肝病毒标志物(HBVM)及前S1抗原。结果302例PHC患者,HBVM检出率为99.0%(299/302)。其中单项阳性率HB sA g 94.0%(284/302)、A n tiHB s 5.6%(17/302)、HB eA g 20.2%(61/302)、A n tiHB e 72.8%(220/302)、A n tiHB c 97.4%(294/302)。61例HB eA g阳性样本中前S1抗原阳性46例(75.4%);而196例HB eA g阴性A n tiHB e阳性标本中前S1抗原阳性98例(50.0%);而35例HB eA g和A n tiHB e均阴性标本中前S1抗原阳性10例(26.3%)。前S1抗原在血清学表达上与HB eA g的阳性符合率高达75.4%。结论血清前S1抗原是乙型肝炎病毒(HBV)在体内复制的可靠标志,通过检测血清前S1抗原有助于提高认识PHC发生的可能性。Objective To investigate the clinical significance of PreS1 in tumorigenesis of primary hepatic cancer （PHC）. Methods The hepatitis B virus and PreS1 were determined by ELISA method in serum of 302 PHC patients. Results Hepatitis B virus markers （HBVM） were detected in 299 of 302 PHC cases with a positive rate of 99.0%, among which HBsAg positive rate was 94. 0% （284/302）,AntiHBs 5.6% （17/302）,HBeAg 20.2%（61/302）,AntiHBe 72.8% （220/302） and AntiHBcAb 97.4%（294/302）. In 46 out of 61 HBeAg positive patients PreS1 antigen was positive with a positive rate of 75.4% ,98 out of 196 HBeAg negative and Anti-HBeAb positive cases had positive PreS1 with a positive rate of 50.0 %. Only 10 cases were found with positive PreS1 in both HBeAg and Anti-HBe negative cases. The coincidence rate of PreS1 and HBeAg was 75.40%. Conclusion PreS1 antigen is the relicable marker of hepatitis B virus in patients with hepatitis B.

关 键 词：癌 肝细胞/诊断 肝炎 乙型/血液 肝炎病毒 乙型/分离和提纯 抗原 病毒/分析 酶联免疫吸附测定 

分 类 号：R735.7[医药卫生—肿瘤]