温州地区汉族人群N-乙酰基转移酶2基因多态性分析  

Analysis of polymorphism of N-acetyltransferase 2 Genotype in Wenzhou Hans

作　　者：邓刚[1] 张雄信[1] 包其郁[1] 

机构地区：[1]浙江温州医学院,温州325035

出　　处：《中国优生与遗传杂志》2006年第12期35-36,25,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨温州地区汉族人群N-乙酰基转移酶2(NAT2)基因多态性分布规律。方法应用聚合酶链反应(PCR)及测序技术对174名温州地区汉族健康人群NAT2 4个突变位点的基因多态性进行检测,并与其它人群进行比较。结果NAT2等位基因频率分别为:W t(59.77%),M2(21.83%),M3(14.36%),M1(4.02%)。未检测到M4突变等位基因。各基因型频率分别为:W t/W t(39.08%),W t/M2(22.99%),W t/M3(14.94%),M2/M3(9.20%),M2/M2(4.60%),W t/M1(3.45%),M1/M2(2.30%),M3/M3(1.72%)M1/M3(1.15%),M1/M1(0.57%)。结论温州地区汉族人群NAT2突变基因中,以M2为主,主要以W t/M2形式存在,M1突变最少,未发现M4。基因多态分布与日本人接近,与其他地区显著不同。Objective ： To determine the distribution of N - acetyltransferase 2 （NAT2） genetic polymorphisms in Wenzhou Hans. Methods ： Genetic polymorphisus of four NAT2 loci in a total of 174 healthy Wenzhou Hans were studied with polymerase chain reaction and sequence determination technique. Current results were compared with the data on other ethnic groups. Results ： The alleles genetic frequencies Wt, M1, M2, M3 were 59. 77% , 4. 02% , 21.83% , 14. 36% respectively. The M4 alleles were not deteeted. While the genotype frequencies of NAT2 polymorphisms were found to be Wt/Wt （39.08%） , Wt/ M2 （22.99%） , Wt/M3 （14.94%） , M2/M3 （9.20%） , M2/M2 （4.60%） , Wt/M1 （3.45%） , M1/M2 （2.30%） , M3/M3 （1.72%） M1/M3 （ 1.15% ） , M1/ M1 （0. 57% ） respectively. Conclusion .. The NAT2 genetic polymorphisms in Wenzhou Hans were similar to those in Japanese population , but were significantly different from those in other areas.

关 键 词：N-乙酰基转移酶基因2 基因多态性 

分 类 号：R394.5[医药卫生—医学遗传学]