LuxS/AI-2密度感应信号及其在口腔致病菌感染中的作用  

LuxS/AI-2 Quorum Sensing and Role in Infection of Oral Pathogenic Bacteria

作　　者：韩福胜[1] 于丹妮[1] 

机构地区：[1]天津医科大学第二医院口腔科,天津300211

出　　处：《医学综述》2006年第23期1409-1411,共3页Medical Recapitulate

基　　金：天津市自然科学基金资助项目(06YFJMJC06900)

摘　　要：密度感应是细菌之间通过分泌和感应胞外信号分子而进行的交流活动,密度感应使细菌同时激活相关基因的表达,协调菌群生物学行为。目前认为AI-2在细菌种间交流中起通用信号分子的作用。LuxS/AI-2参与口腔细菌间的交流,并参与调控毒力因子表达和牙菌斑生物膜的稳定。Quorum sensing is a process of bacterial cell-to-cell communication involving the production and detection of extraecllular signaling molecules called autoinducers. Quorum sensing also activated the expression of related gene at the same time, which coordinates the biological be havior in microbial population. Recently, it has been proposed that autoinducer-2 served as a universal signal for interspecies communication. LuxS/AI-2 is involved in the communication among oral bacteria, regulates the expression of virulence factors and stabilization of biomembrane in dental plaque.

关 键 词：LUXS AI-2 密度感应 口腔致病菌 

分 类 号：R780.2[医药卫生—口腔医学]