细菌演化的天然工具——超级整合子  

Natural tools for bacterial evolution——Super integron

作　　者：张婷[1] 石磊[2] 

机构地区：[1]华南理工大学生物科学与工程学院,广州510640 [2]华南理工大学轻工与食品学院,广州510640

出　　处：《中国抗生素杂志》2006年第12期709-713,共5页Chinese Journal of Antibiotics

摘　　要：已有证据表明整合子是细菌发生水平基因转移和产生耐药机制的主要因素。目前知道的整合子可分为两类:多重抗性整合子和超级整合子。多重抗性整合子基因盒可编码一种或多种耐抗生素和消毒剂基因,存在于转座子、质粒和细菌染色体;超级整合子有的可以同时携带数百个基因盒,可以编码很多不同的功能基因,它们只在细菌的染色体上存在,目前只在特定菌株中发现超级整合子。研究表明,整合子上的基因盒可能最初都来之于超级整合子。本文就超级整合子的结构、分布、起源及它对基因进化产生的影响等几个方面的研究进展进行讨论。Some evidences showed that integrons represent the primary factor for horizontal gene transfer and antibiotic resistance. Integrons could be classified into two groups： the multiple resistance integrons and the super integrons. Multiple resistance integrons mostly carry gene cassettes that encode confer resistance against to one or several antibiotics and disinfectants, and can be located on the transposon, plasmids or chromosome. Super integrons may harbor more than 100 gene cassettes and could encode all kinds of different founction genes, they exist only on the chromosome of bacteria. They were found in several special bacteria. The data identified that gene cassettes of integrons may be originated from super integrons. The structure, distribution, origin of super integrons and their influence on gene evolution were reviewed.

关 键 词：整合子 整合酶 基因盒 超级整合子 

分 类 号：Q78[生物学—分子生物学]