In vitro Potentiation of Antimalarial Activities by Daphnetin Derivatives Against Plasmodium falciparum  

作　　者：FANG HUANG LIN-HUA TANG LIN-QIAN YU YI-CHANG NI QIN-MEI WANG FA-JUN NAN 

机构地区：[1]National Institute of Parasite Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, China [2]Chinese National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 201203, China

出　　处：《Biomedical and Environmental Sciences》2006年第5期367-370,共4页生物医学与环境科学（英文版）

摘　　要：Objective To screen the antimalarial compounds of daphnetin derivatives against Plasmodium falciparum in vitro. Method Plasmodium faciparum （FCC1） was cultured in vitro by a modified method of Trager and Jensen. Antimalarial compounds were screened by microscopy-based assay and microfluorimetric method. Results DA79 and DA78 showed potent antimalarial activity against Plasmodiumfalciparum cultured in vitro. Conclusion Though the relationship between the structures of daphnetin derivatives and their antimalarial activities has not been clarified yet, this study may provide a new direction for discovery of more potential antimalarial compounds.Objective To screen the antimalarial compounds of daphnetin derivatives against Plasmodium falciparum in vitro. Method Plasmodium faciparum （FCC1） was cultured in vitro by a modified method of Trager and Jensen. Antimalarial compounds were screened by microscopy-based assay and microfluorimetric method. Results DA79 and DA78 showed potent antimalarial activity against Plasmodiumfalciparum cultured in vitro. Conclusion Though the relationship between the structures of daphnetin derivatives and their antimalarial activities has not been clarified yet, this study may provide a new direction for discovery of more potential antimalarial compounds.

关 键 词：DAPHNETIN ANTIMALARIAL Drug screening 

分 类 号：R978[医药卫生—药品]