P-糖蛋白和谷胱甘肽硫转移酶在胃癌组织中的表达及其临床意义  

Expression and Clinical Significance of P-glycoprotein and Glutathione-s-transferase in Gastric Cancer

作　　者：郭威[1] 宋光[2] 苑凤昌[1] 

机构地区：[1]齐齐哈尔医学院第一附属医院消化内科,黑龙江省齐齐哈尔市161041 [2]哈尔滨医科大学第一附属医院

出　　处：《中国全科医学》2006年第24期2035-2036,共2页Chinese General Practice

摘　　要：目的观察谷胱甘肽硫转移酶(GST)和多药耐药基因产物P-糖蛋白(P-gp)在胃癌中的表达,探讨两者与胃癌化疗耐药之间的关系。方法应用免疫组化方法定量分析P-gp和GST在75例胃癌标本中的表达,分析两者是否有相关性。结果P-gp和GST在75例胃癌组织中阳性表达率分别为43%和63%,化疗耐药组P-gp和GST阳性表达率与不耐药组比较,差别有显著性意义(P<0·05)。P-gp与GST表达水平呈正相关(r=0·378,P<0·05)。结论P-gp和GST-参与胃癌化疗耐药的机制,可作为多药耐药的标志物。Objective To observe the expression of p - glycoprotein （ P - gp） and glutathione - s - transferase （GST） in gastric cancer and explore the relationship between P - gp, GST and multidrug resistances in patients with gastric cancer. Methods 75 patients with previously untreated gastric cancer were studied for the expression of P - gp and GST by immunohistochemistry, the relativity between them was analyzed. Results The expression rate of G - gp and GST were 43% and 63% in gastric cancer tissues, there was no significant difference in the expression rate of G - gp and GST between drug resistance group and non drug resistance group （ P 〈 0. 05） ; There was a positive correlation between the expression of G - gp and GST （ r = 0. 378, P 〈0.05）, Conclusion P - gp and GST play a part in the mechanism of multidrug resistances, which may be used as the sign of multidrug resistance.

关 键 词：胃肿瘤 P-糖蛋白 谷胱甘肽硫转移酶 多药耐药性 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]