小檗碱降血糖作用的药效学试验与临床疗效观察  

Hypoglycemic Pharmacodynamics and Clinical Efficacy of Berberine

作　　者：郭彬[1] 赵恒侠[1] 

机构地区：[1]广东省深圳市中医院药剂科,广东深圳518033

出　　处：《中国药业》2006年第21期30-31,共2页China Pharmaceuticals

摘　　要：目的研究小檗碱(黄连素)的降血糖作用及临床疗效。方法用四氧嘧啶建立糖尿病小鼠模型,进行药效学试验,并以格列齐特为对照进行临床疗效观察。结果小檗碱对糖尿病小鼠有降血糖作用且有量效关系,可提高其糖耐量和血清胰岛素水平；临床有效率治疗组为80．00%,对照组为76．67%,两组疗效明显但无显著性差异(P＞0．05)。结论小檗碱对糖尿病小鼠和2型糖尿病患者均有降血糖作用。Objective To study the hypoglycemic action of the berberine and its clinical efficacy. Methods To set up the diabetic mice model with alloxan. To randomly divide 70 cases of NIDDM into the berberine group and the control gliclazide group, then the clinical comparison and observation were performend. Results Berberine shorted hypoglycemic action for diabetic mice. It could improve the glucose tolerance and increase the serous level of insulin, which showed centain dose-efiect relationship. The effective rate of 40 cases of NIDDM treated with berberine was 80, 00%, For 30 cases of the control group, the effective rate was 76. 67%. Both groups showed obvious treatment effects without significant difference （P 〉0. 05）. Conclusion Berberinc has hypoglycemic function for diabetic mice and NIDDM.

关 键 词：小檗碱 格列本脲 格列齐特 苯乙双胍 糖尿病小鼠 降血糖 临床疗效 

分 类 号：R285[医药卫生—中药学]