轻度认知损害患者昼夜静息-活动和睡眠-觉醒节律研究  

Studies on circadian rest-activity and sleep-wake rhythm patterns in patients with mild cognitive impairment

作　　者：汪青松[1] 徐芳[1] 许乃银[1] 袁媛[1] 周江宁[2] 

机构地区：[1]解放军第105医院神经内科,合肥230031 [2]中国科学技术大学生命科学学院神经生物学系

出　　处：《解放军医学杂志》2006年第12期1194-1196,共3页Medical Journal of Chinese People's Liberation Army

基　　金：国家重点基础研究发展计划课题(2006CB500705)

摘　　要：目的研究轻度认知损害(MCI)患者昼夜静息-活动和睡眠-觉醒节律的改变。方法使用静息-活动监测仪和睡眠日志研究MCI患者(MCI组)和年龄匹配的健康老年人(对照组)在自然环境下的睡眠与活动情况。结果MCI组的床上时间比对照组显著延长(P<0.01),但实际睡眠时间并无延长;MCI组的睡眠效益比对照组显著下降,睡眠潜伏期延长;MCI组夜间觉醒次数增加,节律破碎指数明显增高。与对照组相比,MCI组的夜间活动量明显增加(P<0.05),而昼夜静息-活动节律的昼夜稳定指数、昼间变异指数和活动节律振幅两组无显著性差异。结论MCI患者的昼夜静息-活动和睡眠-觉醒节律较健康老年人衰弱,并且破碎性增加。Objective To investigate the circadian rest-activity and sleep-wake rhythm patterns in patients with mild cognitive impairment （MCI）. Method Actigraphy and daily record of sleep were used to study the circadian rest-activity and sleep-wake rhythm patterns of the patients with MCI and of 20 age-matched normal people （control group）. Results Compared with control group, the time in bed was significantly longer in MCI group （P〈0. 01）, while there was no significant difference in actual sleep time between MCI group and control group. Compared with control group, there were significant decreased sleep efficiency and prolonged time to fall asleep in MCI group. Also, significant more nighttime wake number, higher frequency of awakening in the night, and higher index of fragmentation of rhythm were observed in MCI group. Though there was no significant difference in daily stability, intradaily variation and activity amplitude of rest-activity rhythm between patients with MCI and normal people, significant higher nighttime activity was found in MCI patients. Conclusion The present study showed that there were significant weakened and fragmented circadian rest-activity, sleep-wake rhythm in patients with MCI.

关 键 词：认知障碍 昼夜静息-活动 睡眠-觉醒节律 

分 类 号：R749.1[医药卫生—神经病学与精神病学] R852.6[医药卫生—临床医学]