辛伐他汀对轻、中度老年痴呆合并高脂血症病人疗效的影响  

Effect of simvastatin on the progress of mild and moderate dementia

作　　者：杨瑞丽[1] 钟伟[1] 崔嫣[1] 

机构地区：[1]山东省枣庄市立医院干部病房,277100

出　　处：《中华神经医学杂志》2006年第12期1261-1263,共3页Chinese Journal of Neuromedicine

摘　　要：目的观察辛伐他汀对轻、中度老年痴呆合并高脂血症病人降血脂疗效和对痴呆进展的影响。方法选择120例轻、中度老年痴呆合并高脂血症病人随机分为研究组和对照组。对照组给予常规治疗,研究组在相同基础上每晚加服辛伐他汀20mg。比较两组治疗前及治疗后4、12周的血清总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及简易智能状态量表(MMSE)、临床痴呆程度量表(CDR)和日常生活自理量表(ADL)分数等指标,以MMSE、CDR和ADL为主要评价指标。结果研究组TC,TG,LDL-C,HDL-C,MMSE、CDR及ADL分数的改善优于对照组,差别有显著性意义(P<0.05)。结论辛伐他汀降血脂同时能延缓轻、中度老年痴呆的进展。Objective To observe the curative effects of simvastatin in treatment of mild and moderate dementia combined with hyperlipidemia. Methods 120 patients with mild and moderate dementia combined with hyperlipideamia were randomly divided into the control group （n=50） and the study group （n=70）. The control group received conventional therapy, while the study group was administrated orally with 20 micrograms of simvastatin every evening. The indices of TC, TG, LDL-C, HDL-C as well as the scores graded by MMSE, CDR and ADL were compared between the groups at week 4 and week 12, respectively. Results The improvements in the indices of TC, TG, LDL-C, HDL-C and the scores of MMSE, CDR and ADL were significantly greater in the study group than in the control group statistically （P〈0.05） Conclusion Simvastatin can postpone the progress of mild and moderate dementia while lowering lipidemia.

关 键 词：辛伐他汀 痴呆 高脂血症 

分 类 号：R749.16[医药卫生—神经病学与精神病学]