EAP化疗联合^(60)Co局部放疗对晚期食管癌伴骨转移患者预后及IL-2系统的影响  

Influence of EAP chemotherapy combined with local radiotherapy on the prognosis and interleukin-2 system of esophageal cancer patients with bone metastasis

作　　者：达炜[1] 宋明全[1] 孙群[1] 朱励[1] 张强[1] 陈金联[1] 王龙[1] 王如华[1] 朱金水[1] 

机构地区：[1]上海交通大学附属第六人民医院消化内科,上海市200233

出　　处：《世界华人消化杂志》2006年第34期3314-3316,共3页World Chinese Journal of Digestology

摘　　要：目的:探讨EAP化疗联合60Co局部放疗对晚期食管癌伴骨转移患者预后及IL-2系统的影响.方法:晚期食管癌伴骨转移患者66例,分静脉化疗联合放疗治疗组和静脉化疗对照组.两组患者在治疗前及1疗程后分别检测IL-2,IL-2R和sIL-2R的水平,并观察其近期疗效.结果:治疗组1疗程的近期有效率及1a生存率显著高于对照组(93.93%vs36.36%,P<0.01;90.90%vs54.54%,P<0.01),并且治疗组IL-2,IL-2R,sIL-2R水平显著高于对照组(23.6±3.12,23.1±3.14,771.4±11.32ng/Lvs44.1±4.07,53.2±5.24,123.2±9.34ng/L,P<0.01).结论:经EAP化疗联合60Co局部放疗治疗骨转移晚期食管癌患者,可显著改善了其IL-2免疫系统的失衡,并能提高晚期食管癌伴骨转移患者的骨痛缓解率、近期有效率及生存率.AIM： To observe the changes of interleukin-2 （IL-2） system and prognosis of esophageal cancer patients with bone metastasis after EAP chemotherapy combined with local radiotherapy. METHODS： A total of 66 advanced esophageal cancer patients with bone metastasis were divided into 2 groups. One group received ^60Co local radiotherapy in combination with the regimen of intravenous chemotherapy at normal dosage of EAP （VP16 100 mg/m^2, topmycine 4 mg/m^2 and carboplatin 60 mg/m^2）, and the other group only received intravenous chemotherapy. The levels of IL-2, IL-2 receptor and soluble IL-2 receptor were detected before and after treatment.RESULTS： The short-term efficacy and 1-year survival rate were significantly higher in the patients with combined treatment than those in the controls （93.93% vs 36.36%, P 〈 0.01; 90.90% vs 54.54%, P 〈 0.01）. Moreover, the levels of IL-2, IL-2 receptor, soluble IL-2 receptor were also markedly higher in the former （23.6 ± 3.12, 23.1 ± 3.14, 771.4 ± 11.32 ng/L vs 44.1 ± 4.07, 53.2 ± 5.24, 123.2 ± 9.34 ng/L, P 〈 0.01）. CONCLUSION： Intravenous chemotherapy in combination with radiotherapy can significantly improve the levels of IL-2, IL-2 receptor, and soluble IL-2 receptor as well as the prognosis of esophageal cancer patients with bone metastasis.

关 键 词：食管癌 IL-2系统 静脉化疗 放疗 

分 类 号：R735.1[医药卫生—肿瘤]